Antioxidant and Protective Effects of Bupleurum falcatum on the L-Thyroxine-Induced Hyperthyroidism in Rats

Figure 4

Representative histopathological profiles on the liver of intact control (a), LT4 control (b), PTU 10 mg/kg (c), BR 300 (d), 150 (e) and 75 (f) mg/kg treated rats. Note that LT4 treatment-related hepatocyte hyperplasia and Reduction of sinusoidal spaces were dramatically inhibited by PTU 10 mg/kg, BR 300, 150, and 75 mg/kg administration. BR: aqueous Bupleuri Radix extracts; LT4: levothyroxine; PTU: propylthiouracil. All H&E stain; scale bars = 80 μm.

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