Antioxidant and Protective Effects of Bupleurum falcatum on the L-Thyroxine-Induced Hyperthyroidism in Rats

Table 2

Serum thyroid hormone levels in the LT4 and testmaterials-treatedrats.

Groups	Serum thyroid hormone concentrations
	Thyroid stimulating hormone (ng/mL)	Triiodothyronine (ng/mL)	Thyroxine (μg/mL)
Controls
Intact	1.57±0.17	0.48±0.18	39.28±11.97
LT4	0.60±0.19^a	1.69±0.20^a	150.40±28.45^a
Reference
PTU 10 mg/kg	1.31±0.17^ac	0.93±0.18^ac	66.88±16.74^ac
BR treated
300 mg/kg	1.40±0.14^bc	0.74±0.18^ac	59.35±13.34^bc
150 mg/kg	1.30±0.16^ac	0.98±0.10^ac	69.37±11.88^ac
75 mg/kg	1.16±0.12^ac	1.15±0.16^ac	87.19±14.98^ac

Values are expressed mean ± S.D. of eight rats. BR: aqueous Bupleuri Radix extracts; LT4: levothyroxine; PTU: propylthiouracil. ^a𝑃<0.01 and ^b𝑃<0.05 as compared with intact control by LSD test; ^c𝑃<0.01 as compared with LT4 control by LSD test.