Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation

Figure 1

RA induces proliferation inhibition of DU145 cells. DU145 cells were treated with different dosages of RA after 1-day serum-free pretreatment. After 2-day or 4-day incubations, cells were performed (a, b) MTT assay, (c, d) BrdU assay, and (e, f) cell number counting as described in Materials and Methods (𝑛=6). Control value of cell proliferation was set at 100%. The values of error bars are given as the mean ± SEM. * and **, 𝑃<0.05 and 𝑃<0.01  versus the group of RA = 0.

(a)

(b)

(c)

(d)

(e)

(f)