Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis
Figure 4
Prohibitin (PHB) induces the transcriptional activity of p53, which promotes expression of Bax. (a) Abrin (ABR)-induced translocation of PHB from cytoplasm to nucleus. (b) ABR upregulates p53 (western blot) and promotes the interaction between PHB and p53 in cells (immunoprecipitated western blot). (c) Association of PHB with the promoter region of the p53-targeted gene Bax.
