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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 615476, 5 pages
http://dx.doi.org/10.1155/2012/615476
Review Article

Auricular Acupuncture May Suppress Epileptic Seizures via Activating the Parasympathetic Nervous System: A Hypothesis Based on Innovative Methods

1Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
2Stronach Research Unit for Complementary and Integrative Laser Medicine, TCM Research Center Graz, and Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine, Medical University of Graz, Auenbruggerplatz 29, 8036 Graz, Austria

Received 12 October 2011; Accepted 26 October 2011

Academic Editor: Lu Wang

Copyright © 2012 Wei He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-H. Liu, Y.-W. Lin, N.-Y. Tang, H.-J. Liu, and C.-L. Hsieh, “Neuroprotective effect of Uncaria rhynchophylla in Kainic acid-induced epileptic seizures by modulating hippocampal mossy fiber sprouting, neuron survival, astrocyte proliferation, and S100b expression,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 194790, 11 pages, 2012. View at Publisher · View at Google Scholar
  2. T. N. Sathyaprabha, P. Satishchandra, C. Pradhan et al., “Modulation of cardiac autonomic balance with adjuvant yoga therapy in patients with refractory epilepsy,” Epilepsy and Behavior, vol. 12, no. 2, pp. 245–252, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. A. W. Yuen and J. W. Sander, “Can slow breathing exercises improve seizure control in people with refractory epilepsy? A hypothesis,” Epilepsy and Behavior, vol. 18, no. 4, pp. 331–334, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Gori and F. Firenzuoli, “Ear acupuncture in European traditional medicine,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 1, pp. 13–16, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. G. N. Asher, D. E. Jonas, R. R. Coeytaux et al., “Auriculotherapy for pain management: a systematic review and meta-analysis of randomized controlled trials,” Journal of Alternative and Complementary Medicine, vol. 16, no. 10, pp. 1097–1108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Oleson, “Auriculotherapy stimulation for neuro-rehabilitation,” NeuroRehabilitation, vol. 17, no. 1, pp. 49–62, 2002. View at Google Scholar · View at Scopus
  7. M. S. Lee, B. C. Shin, L. K. Suen, T. Y. Park, and E. Ernst, “Auricular acupuncture for insomnia: a systematic review,” International Journal of Clinical Practice, vol. 62, no. 11, pp. 1744–1752, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. Lacey, A. M. Tershakovec, and G. D. Foster, “Acupuncture for the treatment of obesity: a review of the evidence,” International Journal of Obesity, vol. 27, no. 4, pp. 419–427, 2003. View at Publisher · View at Google Scholar
  9. X. Y. Gao, S. P. Zhang, B. Zhu, and H. Q. Zhang, “Investigation of specificity of auricular acupuncture points in regulation of autonomic function in anesthetized rats,” Autonomic Neuroscience, vol. 138, no. 1-2, pp. 50–56, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. X. Y. Gao, L. Wang, I. Gaischek, Y. Michenthaler, B. Zhu, and G. Litscher, “Brain-modulated effects of auricular acupressure on the regulation of autonomic function in healthy volunteers,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 714391, 8 pages, 2012. View at Publisher · View at Google Scholar
  11. C. C. Hsu, C. S. Weng, M. F. Sun, L. Y. Shyu, W. C. Hu, and Y. H. Chang, “Evaluation of scalp and auricular acupuncture on EEG, HRV, and PRV,” American Journal of Chinese Medicine, vol. 35, no. 2, pp. 219–230, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. R. La Marca, M. Nedeljkovic, L. Yuan, A. Maercker, and U. Ehlert, “Effects of auricular electrical stimulation on vagal activity in healthy men: evidence from a three-armed randomized trial,” Clinical Science, vol. 118, no. 8, pp. 537–546, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Litscher, “Computer-based quantification of traditional Chinese-, ear- and Korean hand acupuncture: needle-induced changes of regional cerebral blood flow velocity,” Neurological Research, vol. 24, no. 4, pp. 377–380, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Haker, H. Egekvist, and P. Bjerring, “Effect of sensory stimulation (acupuncture) on sympathetic and parasympathetic activities in healthy subjects,” Journal of the Autonomic Nervous System, vol. 79, no. 1, pp. 52–59, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Ueno, H. Sudo, Y. Hattori, K. Yuge, T. Miyaki, and H. Ito, “Innervation of the external ear in humans and the musk shrew,” Nippon Jibiinkoka Gakkai Kaiho, vol. 96, no. 2, pp. 212–218, 1993. View at Google Scholar
  16. I. Tekdemir, A. Asian, and A. Elhan, “A clinico-anatomic study of the auricular branch of the vagus nerve and Arnold's ear-cough reflex,” Surgical and Radiologic Anatomy, vol. 20, no. 4, pp. 253–257, 1998. View at Google Scholar · View at Scopus
  17. D. Gupta, S. Verma, and S. K. Vishwakarma, “Anatomic basis of Arnold's ear-cough reflex,” Surgical and Radiologic Anatomy, vol. 8, no. 4, pp. 217–220, 1986. View at Google Scholar · View at Scopus
  18. D. Engel, “The gastroauricular phenomenon and related vagus reflexes,” Archiv fur Psychiatrie und Nervenkrankheiten, vol. 227, no. 3, pp. 271–277, 1979. View at Google Scholar · View at Scopus
  19. B. Müngen, M. S. Berilgen, and A. Arikanoǧlu, “Autonomic nervous system functions in interictal and postictal periods of nonepileptic psychogenic seizures and its comparison with epileptic seizures,” Seizure, vol. 19, no. 5, pp. 269–273, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. V. V. Novak, A. L. Reeves, P. Novak, P. A. Low, and F. W. Sharbrough, “Time-frequency mapping of R-R interval during complex partial seizures of temporal lobe origin,” Journal of the Autonomic Nervous System, vol. 77, no. 2-3, pp. 195–202, 1999. View at Google Scholar · View at Scopus
  21. M. D. Kanner and M. Andres, “Epilepsy and activity of the autonomic nervous system,” Epilepsy Currents, vol. 2, no. 5, pp. 159–160, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Rauscher, A. C. DeGiorgio, P. R. Miller, and C. M. DeGiorgio, “Sudden unexpected death in epilepsy associated with progressive deterioration in heart rate variability,” Epilepsy and Behavior, vol. 21, no. 1, pp. 103–105, 2011. View at Publisher · View at Google Scholar
  23. S. Mukherjee, M. Tripathi, P. S. Chandra et al., “Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies,” Epilepsy Research, vol. 85, no. 2-3, pp. 261–269, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. R. E. Elliott, A. Morsi, O. Tanweer et al., “Efficacy of vagus nerve stimulation over time: review of 65 consecutive patients with treatment-resistant epilepsy treated with VNS >10years,” Epilepsy and Behavior, vol. 20, no. 3, pp. 478–483, 2011. View at Publisher · View at Google Scholar
  25. T. R. Henry and R. Thomas, “Therapeutic mechanisms of vagus nerve stimulation,” Neurology, vol. 59, no. 6, supplement 4, pp. S3–S14, 2002. View at Google Scholar · View at Scopus
  26. H. A. Sackeim, A. J. Rush, M. S. George et al., “Vagus nerve stimulation (VNS) for treatment-resistant depression: efficacy, side effects, and predictors of outcome,” Neuropsychopharmacology, vol. 25, no. 5, pp. 713–728, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. H. U. Klein and G. M. Ferrari, “Vagus nerve stimulation: a new approach to reduce heart failure,” Cardiology Journal, vol. 17, no. 6, pp. 638–643, 2010. View at Google Scholar
  28. C. Cheyuo, A. Jacob, R. Wu, M. Zhou, G. F. Coppa, and P. Wang, “The parasympathetic nervous system in the quest for stroke therapeutics,” Journal of Cerebral Blood Flow and Metabolism, vol. 31, no. 5, pp. 1187–1195, 2011. View at Publisher · View at Google Scholar
  29. J. L. Zhang, S. P. Zhang, and H. Q. Zhang, “Antiepileptic effects of electroacupuncture vs vagus nerve stimulation on cortical epileptiform activities,” Journal of the Neurological Sciences, vol. 270, no. 1-2, pp. 114–121, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. J. L. Zhang, S. P. Zhang, and H. Q. Zhang, “Antiepileptic effect of electroacupuncture vs. vagus nerve stimulation in the rat thalamus,” Neuroscience Letters, vol. 441, no. 2, pp. 183–187, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Guo, J. Liu, W. Fu et al., “The effect of electroacupuncture on spontaneous recurrent seizure and expression of GAD67 mRNA in dentate gyrus in a rat model of epilepsy,” Brain Research, vol. 1188, no. 1, pp. 165–172, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Shu, R. Y. Liu, and X. F. Huang, “The effects of ear-point stimulation on the contents of somatostatin and amino acid neurotransmitters in brain of rat with experimental seizure,” Acupuncture and Electro-Therapeutics Research, vol. 29, no. 1-2, pp. 43–51, 2004. View at Google Scholar · View at Scopus
  33. J. Shu, R. Y. Liu, and X. F. Huang, “Efficacy of ear-point stimulation on experimentally induced seizure,” Acupuncture and Electro-Therapeutics Research, vol. 30, no. 1-2, pp. 43–52, 2005. View at Google Scholar · View at Scopus
  34. Y. O. Cakmak, “Epilepsy, electroacupuncture and the nucleus of the solitary tract,” Acupuncture in Medicine, vol. 24, no. 4, pp. 164–168, 2006. View at Google Scholar · View at Scopus
  35. N. Soliman and B. L. Frank, “Auricular acupuncture and auricular medicine,” Physical Medicine and Rehabilitation Clinics of North America, vol. 10, no. 3, pp. 547–554, 1999. View at Google Scholar · View at Scopus
  36. T. Granata, H. Cross, W. Theodore, and G. Avanzini, “Immune-mediated epilepsies,” Epilepsia, vol. 52, supplement 3, pp. 5–11, 2011. View at Publisher · View at Google Scholar
  37. A. Vezzani, S. Balosso, and T. Ravizza, “The role of cytokines in the pathophysiology of epilepsy,” Brain, Behavior, and Immunity, vol. 22, no. 6, pp. 797–803, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. W. Y. Chung, H. Q. Zhang, and S. P. Zhang, “Peripheral muscarinic receptors mediate the anti-inflammatory effects of auricular acupuncture,” Chinese Medicine, vol. 6, article 3, 2011. View at Publisher · View at Google Scholar
  39. K. L. Teff, “Visceral nerves: vagal and sympathetic innervation,” Journal of Parenteral and Enteral Nutrition, vol. 32, no. 5, pp. 569–571, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Sato and R. F. Schmidt, “The modulation of visceral functions by somatic afferent activity,” Japanese Journal of Physiology, vol. 37, no. 1, pp. 1–17, 1987. View at Google Scholar · View at Scopus
  41. E. Y. Shen, C. L. Hsieh, Y. H. Chang, and J. G. Lin, “Observation of sympathomimetic effect of ear acupuncture stimulation for body weight reduction,” American Journal of Chinese Medicine, vol. 37, no. 6, pp. 1023–1030, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. D. A. Groves and V. J. Brown, “Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects,” Neuroscience and Biobehavioral Reviews, vol. 29, no. 3, pp. 493–500, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Rinaldi, V. Fontani, L. Aravagli, and P. Mannu, “Psychometric evaluation of a radio electric auricular treatment for stress related disorders: a double-blinded, placebo-controlled controlled pilot study,” Health and Quality of Life Outcomes, vol. 8, article 31, 2010. View at Publisher · View at Google Scholar
  44. S. M. Sator-Katzenschalger and A. Michalek-Sauberger, “P-Stim auricular electroacupuncture stimulation device for pain relief,” Expert Review of Medical Devices, vol. 4, no. 1, pp. 23–32, 2007. View at Publisher · View at Google Scholar · View at Scopus