Table 5: MIC of different antibiotics after the association of the extract of Picralima nitida fruits at MIC/2, MIC/5 against ten MDR bacteria strains.

AntibioticsExtract concentrationBacterial strains, MIC (μg/mL) of antibiotics in the absence and presence of the extract
AG100AG100AtetAG102CM64EA3EA27EA289KP55KP63PA124

CIP0
MIC/2
MIC/5
≤0.5
≤0.5
≤0.5
128
16(8)S
32(4)S
32
16(2)S
16(2)S
≤0.5
≤0.5
≤0.5
256
64(4)S
128(2)S
≤0.5
≤0.5
≤0.5
64
16(4)S
32(2)S
256
128(2)S
256(1)I
128
64(2)S
64(2)S
32
8(4)S
8(4)S
CHL0
MIC/2
MIC/5
4
2(2)S
4(1)I
>512
64(>8)S
128(>4)S
128
16(8)S
32(4)S
512
64(8)S
128(4)S
512
64(8)S
128(4)S
64
8(8)S
32(2)S
512
64(8)S
128(4)S
32
16(2)S
16(2)S
512
128(4)S
256(2)S
64
8(8)S
32(2)S
STR0
MIC/2
MIC/5
4
2(2)S
2(2)S
>512 256(>2)S 512(>1)≤0.5
≤0.5
≤0.5
512
256(2)S
512(1)I
>512
64(8)S
256(>2)S
16
16(1)I
16(1)I
16
16(1)I
16(1)I
16
16(1)I
16(1)I
128
128(1)I
128(1)I
>512
128
512
AMP0
MIC/2
MIC/5
32
16(2)S
16(2)S
>512
512(1)I
>512
256
64(4)S
64(4)S
512
512(1)I
512(1)I
>512
128(>4)S
512(>1)
64
64(1)I
64(1)I
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
16(>32)S
16(>32)S
TET0
MIC/2
MIC/5
64
16(4)S
32(2)S
256
128(2)S
256(1)I
8
1(8)S
4(2)S
128
32(4)S
64(2)S
512
64(8)S
128(4)S
8
2(4)S
4(2)S
32
8(4)S
8(4)S
8
4(2)S
4(2)S
16
8(2)S
8(2)S
8
2(4)S
4(2)S
CLX0
MIC/2
MIC/5
64
32(2)S
32(2)S
>512
>512
>512
>512
128(>4)S
256(>2)S
>512
256
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
>512
512(>1)
>512
KAN0
MIC/2
MIC/5
≤4
≤4
≤4
512
128(4)S
128(4)
16
16(1)I
16(1)I
≤4
≤4
≤4
≤4
≤4
≤4
>512
512(>2)S
>512
32
≤4(>8)S
16(2)I
32
8(4)S
8(4)S
512
128(4)S
512(1)I
128
64(2)S
64(2)S
ERY0
MIC/2
MIC/5
64
32(2)S
64(1)I
512
256(2)S
256(2)S
16
16(1)I
16(1)I
256
32(8)S
256(1)I
32
8(4)S
16(2)S
8
4(2)S
8(1)I
128
128(1)I
128(1)I
64
16(4)S
32(2)S
128
64(2)S
128(1)I
128
8(16)S
8(16)S
NOR0
MIC/2
MIC/5
32
16(2)S
32(1)I
512
128(4)S
128(4)S
128
32(4)S
64(2)S
16
8(2)S
16(1)I
16
4(4)S
16(1)I
32
16(2)S
16(2)S
64
32(2)S
32(2)S
64
32(2)S
32(2)S
64
4(8)S
16(4)S
128
32(4)S
32(4)S
FEP 0
MIC/2
MIC/5
512
256(2)S
512(1)I
512
128(4)S
512(1)I
512
512(1)I
512(1)I
>512
256(>4)S
>512
256
64(4)S
128(2)S
512
252(2)S
512(1)I
512
512(1)I
512(1)I
>512
>512
>512
512
256(2)S
512(1)I
512
512(1)I
512(1)I

(): fold increase in MIC values of the antibiotics after association with plants extract; S: synergy, I: indifference; AMP: ampicillin; FEP: cefepime; CHL: chloramphenicol; KAN: kanamycin; NOR: norfloxacin; STR: streptomycin; TET: tetracycline; CIP: ciprofloxacin; CLX: cloxacillin; ERY: erythromycin.