Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder

Table 1

The effects of repeated treatment with Ser or Flavonoids on the level of monoamine and its metabolite (ng/g tissue) in hippocampus and prefrontal cortex of rats subjected to SPS. Data are presented as the mean ± SEM, 𝑛= 4–6. *𝑃<0.05, compared with SPS (−); ^##𝑃<0.01 compared with SPS (ANOVA followed by Dunnett's t-test).

Groups	SPS (−)	SPS + saline	SPS + Ser (mg/kg)	SPS + Flavonoids (mg/kg)
			15	12.5	25	50
Hippocampus
5-HT	156.80±5.42	118.20±3.192 *	199.21±12.26^##	153.81±10.93	172.00±13.79^##	178.40±9.90^##
5-HIAA	456.20±20.69	415.60±36.16	343.60±21.02^##	465.60±37.50	494.90±38.21	484.40±17.65
NE	155.90±14.95	198.10±23.71	182.70±24.92	157.40±7.77	187.50±17.51	191.60±22.08
DA	19.58±3.20	22.94±3.13	14.33±0.99	15.49±2.39	15.45±1.33	17.46±2.24
DOPAC	34.27±7.69	32.22±3.110	29.12±2.91	26.35±3.44	28.82±2.18	30.12±3.45
Prefrontal cortex
5-HT	238.31±11.47	257.45±16.23	255.90±39.32	233.20±16.11	231.40±15.89	264.31±18.66
5-HIAA	371.82±5.60	313.0±45.29	458.50±27.56^#	402.90±22.88	404.50±20.44	445.50±21.27^#
NE	129.30±16.21	155.0±9.65	137.60±17.86	124.80±15.77	133.00±11.24	146.80±16.47
DA	48.09±2.43	50.36±8.22	49.87±4.69	43.14±3.76	36.25±5.26	44.44±0.98
DOPAC	33.23±2.69	36.67±2.77	39.88±5.25	35.77±2.66	33.57±1.47	36.04±2.89