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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 635702, 10 pages
http://dx.doi.org/10.1155/2012/635702
Research Article

Tumor Microenvironment Varies under Different TCM ZHENG Models and Correlates with Treatment Response to Herbal Medicine

1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Received 11 January 2012; Accepted 1 April 2012

Academic Editor: Shi-Bing Su

Copyright © 2012 Zhen Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. P. Lu, X. R. Ding, and K. J. Chen, “Current situation and progress in integrative medicine in China,” Chinese Journal of Integrative Medicine, vol. 14, no. 3, pp. 234–240, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Hanahan and R. A. Weinberg, “Hallmarks of cancer: the next generation,” Cell, vol. 144, no. 5, pp. 646–674, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Pietras and A. Östman, “Hallmarks of cancer: interactions with the tumor stroma,” Experimental Cell Research, vol. 316, no. 8, pp. 1324–1331, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Y. Dai, Peng Wang, L. Y. Feng et al., “The molecular mechanisms of traditional Chinese medicine ZHENG syndromes on pancreatic tumor growth,” Integrative Cancer Therapies, vol. 9, no. 3, pp. 291–297, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. Z. Chen, L.-M. Liu, and Y.-B. Liu, “Characteristics of W256 tumor growth and liver metastasis in mice model with Blood stasis syndrome,” Zhong Yi Yao Xue Kan, vol. 21, no. 6, pp. 866–867, 2003. View at Google Scholar
  6. J. A. Joyce and J. W. Pollard, “Microenvironmental regulation of metastasis,” Nature Reviews Cancer, vol. 9, no. 4, pp. 239–252, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Polyak, I. Haviv, and I. G. Campbell, “Co-evolution of tumor cells and their microenvironment,” Trends in Genetics, vol. 25, no. 1, pp. 30–38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Neesse, P. Michl, K. K. Frese et al., “Stromal biology and therapy in pancreatic cancer,” Gut, vol. 60, no. 6, pp. 861–868, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. L. A. Kunz-Schughart and R. Knuechel, “Tumor-associated fibroblasts (Part I): active stromal participants in tumor development and progression?” Histology and Histopathology, vol. 17, no. 2, pp. 599–621, 2002. View at Google Scholar · View at Scopus
  10. A. Mantovani and A. Sica, “Macrophages, innate immunity and cancer: balance, tolerance, and diversity,” Current Opinion in Immunology, vol. 22, no. 2, pp. 231–237, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Steidl, T. Lee, S. P. Shah et al., “Tumor-associated macrophages and survival in classic Hodgkin's lymphoma,” The New England Journal of Medicine, vol. 362, no. 10, pp. 875–885, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Mantovani, T. Schioppa, C. Porta, P. Allavena, and A. Sica, “Role of tumor-associated macrophages in tumor progression and invasion,” Cancer and Metastasis Reviews, vol. 25, no. 3, pp. 315–322, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. N. A. Bhowmick, E. G. Neilson, and H. L. Moses, “Stromal fibroblasts in cancer initiation and progression,” Nature, vol. 432, no. 7015, pp. 332–337, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Marchesi, P. Monti, B. E. Leone et al., “Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4,” Cancer Research, vol. 64, no. 22, pp. 8420–8427, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Ouyang, P. Wang, Z. Meng et al., “Multimodality treatment of pancreatic cancer with liver metastases using chemotherapy, radiation therapy, and/or Chinese herbal medicine,” Pancreas, vol. 40, no. 1, pp. 120–125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Wang, Z. Chen, Z. Q. Meng et al., “Ski acts as therapeutic target of Qingyihuaji formula in the treatment of SW1990 pancreatic cancer,” Integrative Cancer Therapies, vol. 9, no. 1, pp. 50–58, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. R. R. Langley and I. J. Fidler, “The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs,” International Journal of Cancer, vol. 128, no. 11, pp. 2527–2535, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Mahadevan and D. D. Von Hoff, “Tumor-stroma interactions in pancreatic ductal adenocarcinoma,” Molecular Cancer Therapeutics, vol. 6, no. 4, pp. 1186–1197, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. W. J. Wang, “Pay more attention to “Analogous syndrome complex in the same disease and treating the same disease with analogous methods”,” Zhong Xi Yi Jie He Xue Bao, vol. 6, no. 5, pp. 441–445, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. L. M. Liu, “The prospective of integrative medical treatment of oncology in the next ten years,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 31, no. 7, pp. 870–872, 2011. View at Google Scholar
  21. Y.-H. Shen, L.-M. Liu, Z. Chen et al., “Combined with chemotherapy for treatment of 32 cases of advanced pancreatic cancer,” Journal of Traditional Chinese Medicine, vol. 47, no. 2, pp. 115–117, 2006. View at Google Scholar