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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 647620, 9 pages
http://dx.doi.org/10.1155/2012/647620
Research Article

Mapuche Herbal Medicine Inhibits Blood Platelet Aggregation

1Department of Plant Biology and Biotechnology, VKR Research Centre Pro-Active Plants, Faculty of Life Sciences, University of Copenhagen, 1871 Copenhagen, Denmark
2Health and Nutrition Division, Chr. Hansen A/S, 2970 Hørsholm, Denmark
3Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark

Received 19 July 2011; Revised 18 August 2011; Accepted 19 August 2011

Academic Editor: Ulysses Paulino De Albuquerque

Copyright © 2012 Susan Skanderup Falkenberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0  M) and collagen- (2.0  g/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H2O), Amomyrtus luma (DCM : MeOH 1 : 1) and Cestrum parqui (DCM : MeOH 1 : 1). The platelet aggregating inhibitory effects of A. luma (DCM : MeOH 1 : 1), and L. apiculata (H2O) were substantial and confirmed by inhibition of platelet surface activation markers.