Mapuche Herbal Medicine Inhibits Blood Platelet Aggregation
Table 2
Mapuche medicinal plant extracts tested in sheep blood. The agonists are ADP (5.0 μM) and collagen (5.0 μg/mL) and the obtained aggregations are shown in percentage. Extracts are tested in 0.1 mg/mL end concentrations. The aggregation is shown for both extract and vehicle control. If the extract aggregation is 20% lower than that of the vehicle control inhibition is observed.
Plant
Extract
Extract Yield (% dw)
Agonist
% Aggregation (extract)
% Aggregation (vehicle control)
% Inhibition
Inhibition
Amomyrtus luma (leaf)
DCM : MeOH 1 : 1
6.8
ADP
47
88
47
Yes
Collagen
25
85
71
Yes
MeOH
14.4
ADP
61
60
−2
No
Collagen
30
83
64
Yes
H2O
6.7
ADP
45
68
34
Yes
Collagen
23
86
73
Yes
Anthoxanthum utriculatum (leaf)
DCM : MeOH 1 : 1
5.2
ADP
38
49
22
Yes
Collagen
106
124
15
*1
MeOH
4.9
ADP
33
68
51
Yes
Collagen
22
77
71
Yes
H2O
4.8
ADP
50
51
2
No
Collagen
39
75
48
Yes
Blechnum chilense (leaf)
DCM : MeOH 1 : 1
2.8
ADP
52
62
16
No
Collagen
26
44
41
Yes
MeOH
1.8
ADP
38
52
27
Yes
Collagen
1
18
94
Yes
Cestrum parqui (leaf)
DCM : MeOH 1 : 1
7.6
ADP
49
81
40
Yes
Collagen
27
91
70
Yes
MeOH
3.7
ADP
44
77
43
Yes
Collagen
30
83
64
Yes
H2O
15.9
ADP
73
82
11
*1
Collagen
52
82
37
Yes
Corynabutilon vitifolium (leaf)
DCM : MeOH 1 : 1
3.6
ADP
48
54
11
No
Collagen
44
35
−26
No
MeOH
3.7
ADP
39
59
34
*1
Collagen
48
49
2
No
Fuchsia magellanica (leaf)
DCM : MeOH 1 : 1
12.2
ADP
45
45
0
No
Collagen
10
12
17
No
MeOH
6.2
ADP
30
52
42
Yes
Collagen
32
38
16
No
Gunnera chilensis (leaf + stem)
DCM : MeOH 1 : 1
13.1
ADP
50
59
15
No
Collagen
49
64
23
Yes
MeOH
3.3
ADP
40
56
29
*1
Collagen
35
65
46
Yes
H2O
6.5
ADP
50
71
30
*1
Collagen
68
56
−21
*1
Lomatia ferruginea (leaf)
DCM : MeOH 1 : 1
2.7
ADP
24
55
56
Yes
Collagen
9
33
73
Yes
MeOH
1.1
ADP
43
50
14
No
Collagen
6
55
89
*2
H2O
6.9
ADP
57
43
−33
No
Collagen
30
50
40
*1
Luma apiculata (leaf)
DCM : MeOH 1 : 1
4.5
ADP
51
65
22
*1
Collagen
42
75
44
*1
MeOH
4.9
ADP
18
52
65
Yes
Collagen
20
64
69
Yes
H2O
9.1
ADP
19
56
66
Yes
Collagen
21
74
72
Yes
Pluchea absinthioides (leaf)
DCM : MeOH 1 : 1
8.9
ADP
47
57
18
*1
Collagen
17
39
56
Yes
MeOH
2.9
ADP
48
50
4
No
Collagen
10
36
72
Yes
H2O
4.4
ADP
43
51
16
No
Collagen
9
51
82
*2
Pseudopanax laetevirens (leaf)
DCM : MeOH 1 : 1
7.3
ADP
45
59
24
Yes
Collagen
23
61
62
Yes
MeOH
6.2
ADP
43
57
25
*1
Collagen
4
60
93
Yes
H2O
13.3
ADP
50
66
24
Yes
Collagen
8
6
−33
No
Satureja multiflora (leaf + stem)
DCM : MeOH 1 : 1
7.2
ADP
44
74
41
Yes
Collagen
31
81
62
*1
MeOH
7.1
ADP
60
67
10
No
Collagen
44
125
65
*1
H2O
14.3
ADP
61
64
5
No
Collagen
11
43
74
*2
*1: Aggregation curve and output % does not correlate, and the result is doubtful.
*2: Aggregation curve is very flat, this is suspicious.
