Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
Figure 1
Representative Dixon plots for inhibitory effects of (a) DA-9701, (b) Corydalis Tuber extract, and (c) quinidine on CYP2D6-catalyzed bufuralol 1′-hydroxylation in pooled human liver microsomes, H161. Each symbol represents the bufuralol concentration: 0.5 M (∇), 1.0 M (◯), 2.0 M (∆), and 5.0 M (□). Each data point represents the mean of triplicate experiments.
