Guizhi-Fuling-Wan, a Traditional Chinese Herbal Medicine, Ameliorates Memory Deficits and Neuronal Apoptosis in the Streptozotocin-Induced Hyperglycemic Rodents via the Decrease of Bax/Bcl2 Ratio and Caspase-3 Expression

Figure 3

Effect of GFW (1.0, 2.0, and 4.0 g/kg) on the swimming time taken to reach the hidden platform of the Morris water maze (a) and the time spent in the target quadrant (b) in hyperglycemia mice. The performance of each mouse was tested 24 hours after the final training day in a probe trial (60 sec) during which the platform was removed. *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 compared to the normal group. ^#𝑃<0.05, ^##𝑃<0.01, ^###𝑃<0.001 compared to hyperglycemia group (𝑛=8 in each group).

(a)

(b)