Guizhi-Fuling-Wan, a Traditional Chinese Herbal Medicine, Ameliorates Memory Deficits and Neuronal Apoptosis in the Streptozotocin-Induced Hyperglycemic Rodents via the Decrease of Bax/Bcl2 Ratio and Caspase-3 Expression

Figure 5

Effects of GFW on cleaved caspase-3 positive cells in the cortex and hippocampus CA2 of hyperglycemic rats. (a), (d) Normal; (b), (e) hyperglycemia; (c), (f): treated with GFW 4 g/kg of hyperglycemic rats. The arrow was showing the cleaved caspase-3 positive cells. (g) Bar chart of cleaved caspase-3 positive cells in the cortex and hippocampus (CA1, CA2, and CA3) of normal rats, hyperglycemic rats, and hyperglycemic rats treated with GFW (1.0, 2.0, and 4.0 g/kg). ***𝑃<0.001 versus normal group. ^#𝑃<0.05, ^##𝑃<0.01, ^###𝑃<0.001 versus hyperglycemia group (𝑛=6 in each group). Scale bar = 50 𝜇m.

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