Figure 1: Experimental schedules of corticosterone-induced impairment of spatial memory in the rat. Black arrows indicate acupuncture treatments. Experiment 1 was designed to compare the CORT concentration in rat blood and brain tissue, immediately after CORT injection or immobilization stress for 21 days. It also was designed to compare the effects of acupuncture stimulation to enhanced CORT concentration in the blood of chronic CORT-injected rats for 21 days. Experiment 2 was designed to explore the efficacy of acupuncture therapy for healing chronic CORT-induced spatial memory impairment in an animal model using behavioral and neurobiological methodologies. IHC; Immunohistochemistry.