A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
Figure 1
Mast cell-related mediators: Prostaglandin D2 (a) and histamine (b). Anti-IgE resulted in a significant increase in prostaglandin D2 (PGD2) and histamine release within 30 minutes after tissue exposure in nasal polyp mucosal tissue. In comparison to tissue culture medium, S. baicalensis, but not E. senticosus (data not shown), significantly reduced the release of de novo synthesized PGD2 at a concentration of 2 μg/mL (high) in nasal polyps. The combination of S. baicalensis and E. senticosus, however, had a more potent effect on the release of PGD2 in nasal polyp tissue and reached significance already at a low concentration of 0,2 μg/mL of each compound after anti-IgE stimulation (a). The combination of S. baicalensis and E. senticosus had a similarly strong suppressive effect at a low concentration of 0.2 μg/mL to reduce the release of histamine (b).
