A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
Figure 3
T-cell activation-related release of cytokines. (a) SEB resulted in a significant release of IL-1, TNF-α, IFN-γ, IL-2, IL-5, and IL-17 from nasal polyp tissue, indicating the stimulation of all prominent T helper cell populations. Although single components demonstrated suppressive activity, this suppression remained insignificant; only the combination of S. baicalensis and E. senticosus at a concentration of 2 μg/mL of each compound resulted in a significant, nearly complete suppression of the release of IFN, IL-5, IL-1β and TNF-α 6 h after SEB stimulation, and a partial suppression for IL-17 and IL-2. (b) The suppressive activity of the combination was superior to that of an established topical corticosteroid, fluticasone propionate (FP), for IFN-γ, IL-1β, TNF-α, and IL-17 and equivalent for IL-5 and IL-2.
