Evaluation of Safety and Protective Effect of Combined Extract of <i>Cissampelos pareira</i> and <i>Anethum graveolens</i> (PM52) against Age-Related Cognitive Impairment

<table>Effect of Donepezil, Vitamin C, and various doses of PM52 ranging from 2, 10, and 50 mg/kg BW on neuron density in CA3 of hippocampus of memory impairment rats induced by AF64A. Values are expressed as mean ± SEM. (<svg height="11.125" id="M24" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.125" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>/group) <sup>a,aa,aaa</sup><svg height="11.175" id="M25" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.9375 11.175" width="10.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,11.113)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg>-value &lt; .05, .01 and .001 compared with vehicle plus ACSF-treated group, <sup>*,**,***</sup><svg height="11.175" id="M26" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.9375 11.175" width="10.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>-value &lt; .05, .01 and .001 compared with vehicle plus AF64A-treated group.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 4

Figure 4: Evaluation of Safety and Protective Effect of Combined Extract of <i>Cissampelos pareira</i> and <i>Anethum graveolens</i> (PM52) against Age-Related Cognitive Impairment 

Figure 4 | Evaluation of Safety and Protective Effect of Combined Extract of Cissampelos pareira and Anethum graveolens (PM52) against Age-Related Cognitive Impairment 