TY - JOUR
A2 - Liu, I-Min
AU - Chang, Shih-Sheng
AU - Lee, Viola S. Y.
AU - Tseng, Yu-Lun
AU - Chang, Kuan-Cheng
AU - Chen, Kuen-Bao
AU - Chen, Yuh-Lien
AU - Li, Chi-Yuan
PY - 2012
DA - 2012/06/28
TI - Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β
SP - 683872
VL - 2012
AB - Platelet activation and its interaction with leukocytes play an important role in atherothrombosis. Cardiovascular diseases resulted from atherothrombosis remain the major causes of death worldwide. Gallic acid, a major constituent of red wine and tea, has been believed to have properties of cardiovascular protection, which is likely to be related to its antioxidant effects. Nonetheless, there were few and inconsistent data regarding the effects of gallic acid on platelet function. Therefore, we designed this in vitro study to determine whether gallic acid could inhibit platelet activation and the possible mechanisms. From our results, gallic acid could concentration-dependently inhibit platelet aggregation, P-selectin expression, and platelet-leukocyte aggregation. Gallic acid prevented the elevation of intracellular calcium and attenuated phosphorylation of PKCα/p38 MAPK and Akt/GSK3β on platelets stimulated by the stimulants ADP or U46619. This is the first mechanistic explanation for the inhibitory effects on platelets from gallic acid.
SN - 1741-427X
UR - https://doi.org/10.1155/2012/683872
DO - 10.1155/2012/683872
JF - Evidence-Based Complementary and Alternative Medicine
PB - Hindawi Publishing Corporation
KW -
ER -