TY - JOUR A2 - Liu, I-Min AU - Chang, Shih-Sheng AU - Lee, Viola S. Y. AU - Tseng, Yu-Lun AU - Chang, Kuan-Cheng AU - Chen, Kuen-Bao AU - Chen, Yuh-Lien AU - Li, Chi-Yuan PY - 2012 DA - 2012/06/28 TI - Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β SP - 683872 VL - 2012 AB - Platelet activation and its interaction with leukocytes play an important role in atherothrombosis. Cardiovascular diseases resulted from atherothrombosis remain the major causes of death worldwide. Gallic acid, a major constituent of red wine and tea, has been believed to have properties of cardiovascular protection, which is likely to be related to its antioxidant effects. Nonetheless, there were few and inconsistent data regarding the effects of gallic acid on platelet function. Therefore, we designed this in vitro study to determine whether gallic acid could inhibit platelet activation and the possible mechanisms. From our results, gallic acid could concentration-dependently inhibit platelet aggregation, P-selectin expression, and platelet-leukocyte aggregation. Gallic acid prevented the elevation of intracellular calcium and attenuated phosphorylation of PKCα/p38 MAPK and Akt/GSK3β on platelets stimulated by the stimulants ADP or U46619. This is the first mechanistic explanation for the inhibitory effects on platelets from gallic acid. SN - 1741-427X UR - https://doi.org/10.1155/2012/683872 DO - 10.1155/2012/683872 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi Publishing Corporation KW - ER -