Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Tab 3

Review Article

Traditional Chinese Medicine for Senile Dementia

Table 3

Memory-improving and neuro-protective effects of Poria cocos.

TestTest materials/doseTest modelEndpoints/biomarkersEffectsReference

In vivo Extracts 20–100 mg/kgScopolamine-treated ratsEight-arm radial mazeImprove spatial memory[20]
Extracts 250–500 mg/kgInnate ratsElectro-physiology Spike amplitudeEnhance hippocampal LTP[21]
Methanol extracts 200 mg/mLEllman ChEChE activityInhibit ChE by 27.8%[22]
Aqueous extracts 0.2 mg/mLInnate ICR miceAChE activityInhibit AChE by 13.9%[23]

In vitroAqueous extracts 31–250 μg/mLBrain neurons–neonatal ratsCytosolic [Ca2+] iRegulate bi-directly [Ca2+] i[24]

Long-term potentiation (LTP); choline esterase (ChE); acetylcholinesterase (AChE).

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