Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Tab 5

Review Article

Traditional Chinese Medicine for Senile Dementia

Table 5

Memory-improving and neuro-protective effects of Radix et rhizoma glycyrrhizae.

TestTest materials /doseTest modelEndpoint/biomarkersEffectsMechanismsReference

In vivo Extracts 75–300 mg/kg, 7d diet 0.5 or 1%, 6wDiazepam treated miceElevated plus-maze testImprove memoryCholinergic[50]
Scopolamine treated micepassive avoidance test[51]
Aβ 25–35 treated micepassive avoidance testMorris water-maze test TBARS/Catalase/AChEImprove memoryQuench oxidative stress Inhibit AChE[52]
Aqueous extracts 150 mg/kg, 7d n-hexane extracts 5 mg/kg, 3dInnate miceAChEInhibit AChEN.A.[53]
Methanol extract 50–100 mg/kg, 21dIR treated Mongolian gerbilsCu, Zn-SOD1CA1 pyramidal cellsProtect neuronsRestore Cu, Zn-SOD1[54]
Liquiritigenin 2.3–21 mg/kg, 7dAβ (25–35)-treated ratsMorris water maze testReference memory taskProbe taskTwo-way shuttle avoidance taskMAP, Nissle, Notch-2[55]

In vivo Isoliquiritigenin 5–20 mg/kg, 7dMCAO-treated ratsMDASOD,GSH-Px, CatalaseNa+-K+-ATPase, ATPEnergy charge, total adenine nucleotidesProtect brainPromote energy metabolismInhibit oxidative stress[56]
Glabridin 1–4 mg/kg, 3dInnate MiceChEImprove memoryInhibit ChE[57]
Glabridin 5–25 mg/kgIR-treated rats Staurosporine-treated neuronsMDA, GSH and SODBax, caspase-3,bcl-2Protect neuronsInhibit apoptosisInhibit oxidative stress[58]

Acetylcholinesterase (AChE); cholinesterase (ChE); thiobarbituric acid-reactive substances (TBARS); superoxide dismutase (SOD); malondialdehyde (MDA); glutathione (GSH); microtubule-associated protein (MAP) 2; middle cerebral artery occlusion (MCAO); β amyloid (Aβ); Ischemia-reperfusion (IR); not available (N.A.).

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