Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Tab 6

Review Article

Traditional Chinese Medicine for Senile Dementia

Table 6

(a) Memory-improving and neuro-protective effects of Radix Angelica sinensis

TestTest materials/doseTest modelEndpoint/biomarkersEffectsMechanismsReference

In vivoExtracts 1 g/kgscopolamine-treated rats cycloheximide-treated ratsStep-through testImprove memoryN.A.[62]
In vitroExtracts 25–200 μg/mlAβ-treated Neuro 2A cellsMTT assay/ΔΨm ROS/LPO/GSHProtect neuronsQuench oxidative stress[63]

3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT); Lipid peroxidation (LPO); mitochondrial transmembrane potential (ΔΨm); β amyloid (Aβ); glutathione (GSH); not available (N.A.).
(b) Memory-improving and neuro-protective effects of active components from Radix Angelica sinensis

TestTest materials/doseTest modelEndpoint/biomarkersEffectsMechanismsReference

In vivo Ferulic acid s.c., 5 mg/kg/d, 6 ddl-buthionine-(S,R)-Sulfoximine treated miceObject recognition test Oxidative carbonyl proteinImprove memoryElevate carbonyl protein[66]
Ferulic acid 28 dTrimethyltin-treated miceY-maze testPassive avoidance testChATImprove memoryActivate ChAT[67]
Ferulic acid i.p., 20–80 mg/kg, 3 dGlutamate-treated miceBehavioral test histopathology [(3)H]-labeled glutamate bcl-2/caspase-3Protect brainNMDA receptor antagonist[68]
Ferulic acid 0.006%, 4 wAβ1-42-treated miceStep-through test Y-maze test Water maze test GFAP/IL-1 βImprove memoryProtect brainSuppress astrocytes immunoreactivities[69]
Ferulic acid 50–100 mg/kgScopolamine-treated rats Cycloheximide-treated ratsStep-through testImprove memoryCholinergic Enhance CBF[70]
Z-ligustilide 10–40 mg/kg, 4 wCCAO-treated ratsMorris water maze Neurons/astrocytes count MDA/SOD/ChAT/AChEImprove memoryInhibit oxidative stress Cholinergic[71]
Z-ligustilide 20–80 mg/kgMCAO-treated ratsTTC staining Brain swelling Behavioural scoreProtect brainN.A.[72]
Z-ligustilide 5–20 mg/kgIR-treated ICR miceTTC staining MDA/GSH-Px/SOD Bcl-2/Bax/caspase-3Protect brainInhibit oxidative stress Inhibit apoptosis[73]

Choline acetyltransferase (ChAT); cerebral blood flow (CBF); glial fibrillary acidic protein (GFAP); interleukin-1 (IL-1); glutathione peroxidase (GSH-PX); 2,3,5-triphenyltetrazolium chloride (TTC); subcutaneously (s.c.); ischemia-reperfusion (IR); superoxide dismutase (SOD); malondialdehyde (MDA); acetylcholinesterase (AChE); common carotid arteries occlusion (CCAO); middle cerebral artery occlusion (MCAO); β amyloid (Aβ); N-methyl-D-aspartate (NMDA); not available (N.A.).

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