Table 1: Significantly enriched KEGG biological pathways among top 0.1% candidate target genes of QSKL compositive compounds.

KEGG pathway number and name value Coverage

hsa04080 neuroactive ligand-receptor interaction 0.1358
hsa00970 aminoacyl-tRNA biosynthesis 0.3171
hsa04020 calcium signaling pathway 0.1348
hsa00260 glycine, serine, and threonine metabolism 0.2258
hsa04614 renin-angiotensin system 0.2941
hsa00290 valine, leucine, and isoleucine biosynthesis 0.3636
hsa00590 arachidonic acid metabolism 0.1552
hsa00350 tyrosine metabolism 0.1522
hsa04260 cardiac muscle contraction 0.1125
hsa00330 arginine and proline metabolism 0.1296
hsa04270 vascular smooth muscle contraction 0.0960
hsa00250 alanine, aspartate, and glutamate metabolism 0.1613
hsa04144 endocytosis 0.0802
hsa04115 p53 signaling pathway 0.1014
hsa00071 fatty acid metabolism 0.1190
hsa00591 linoleic acid metabolism 0.1379

A pathway is significantly enriched with candidate target genes when its corresponding upper-tailed value of hypergeometric cumulative distribution is smaller than 0.05. The pathways are ranked according to the order of the increasing values. The coverage for each pathway is referred to as the fraction of candidate target genes among all the pathway member genes.