Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction
Figure 2
Mean (S.E.) serum concentration-time profiles of PHT (a), HPPH (b), PHT-G (c), and HPPH-G (d) after oral administration of PHT alone (200 mg/kg) (°), coadministration with single dose (●), and 7th dose of 2 g/kg (■) of RP decoction in six rats.
