Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 708156, 8 pages
http://dx.doi.org/10.1155/2012/708156
Research Article

Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect

1Morphology Department, Biosciences Institute, UNESP-University Estadual Paulista, P.O. Box 510, 18618-970 Botucatu, SP, Brazil
2Physiology Department, Biosciences Institute, UNESP-University Estadual Paulista, 18618-970 Botucatu, SP, Brazil

Received 26 January 2012; Accepted 29 February 2012

Academic Editor: José Luis Ríos

Copyright © 2012 A. L. Rozza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Laine, K. Takeuchi, and A. Tarnawski, “Gastric mucosal defense and cytoprotection: bench to bedside,” Gastroenterology, vol. 135, no. 1, pp. 41–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. M. G. Repetto and S. F. Llesuy, “Antioxidant properties of natural compounds used in popular medicine for gastric ulcers,” Brazilian Journal of Medical and Biological Research, vol. 35, no. 5, pp. 523–534, 2002. View at Google Scholar · View at Scopus
  3. F. K. L. Chan and W. K. Leung, “Peptic-ulcer disease,” The Lancet, vol. 360, no. 9337, pp. 933–941, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. M. J. Blaser, “Disappearing microbiota: Helicobacter pylori protection against esophageal adenocarcinoma.,” Cancer Prevention Research, vol. 1, no. 5, pp. 308–311, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. W. D. Chey and B. C. Y. Wong, “American College of Gastroenterology guideline on the management of Helicobacter pylori infection,” American Journal of Gastroenterology, vol. 102, no. 8, pp. 1808–1825, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. K. M. Fock, P. Katelaris, K. Sugano et al., “Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection,” Journal of Gastroenterology and Hepatology, vol. 24, no. 10, pp. 1587–1600, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Malfertheiner, F. Megraud, C. O'Morain et al., “Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report,” Gut, vol. 56, no. 6, pp. 772–781, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. O. A. Paoluzi, E. Visconti, F. Andrei et al., “Ten and eight-day sequential therapy in comparison to standard triple therapy for eradicating Helicobacter pylori infection: a randomized controlled study on efficacy and tolerability,” Journal of Clinical Gastroenterology, vol. 44, no. 4, pp. 261–266, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Selgrad and P. Malfertheiner, “Treatment of Helicobacter pylori,” Current Opinion in Gastroenterology, vol. 27, pp. 565–570, 2011. View at Google Scholar
  10. A. Samie, C. L. Obi, P. O. Bessong, and L. Namrita, “Activity profiles of fourteen selected medicinal plants from Rural Venda communities in South Africa against fifteen clinical bacterial species,” African Journal of Biotechnology, vol. 4, no. 12, pp. 1443–1451, 2005. View at Google Scholar · View at Scopus
  11. S. Al-Khalil, “A survey of plants used in Jordanian traditional medicine,” International Journal of Pharmacognosy, vol. 33, no. 4, pp. 317–323, 1995. View at Google Scholar · View at Scopus
  12. WHO, Monographs on Selected Medicinal Plants, WHO, Geneva, Switzerland, 1999.
  13. A. Gescher, “New perspectives on dietary polyphenols: taking stock, more to come,” Molecular Nutrition & Food Research, vol. 54, pp. S125–S126, 2010. View at Google Scholar
  14. M. A. Andreo, K. V. R. Ballesteros, C. A. Hiruma-Lima, L. R. Machado da Rocha, A. R. M. Souza Brito, and W. Vilegas, “Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection,” Journal of Ethnopharmacology, vol. 107, no. 3, pp. 431–441, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Jahovic, G. Erkanli, S. Işeri, S. Arbak, and I. Alican, “Gastric protection by α-melanocyte-stimulating hormone against ethanol in rats: involvement of somatostatin,” Life Sciences, vol. 80, no. 11, pp. 1040–1045, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. M. E. Anderson, “Determination of glutathione and glutathione disulfide in biological samples,” Methods in Enzymology, vol. 113, pp. 548–555, 1985. View at Google Scholar · View at Scopus
  17. I. Puscas, C. Puscas, M. Coltau et al., “Comparative study of the safety and efficacy of ebrotidine versus ranitidine and placebo in the prevention of piroxicam-induced gastroduodenal lesions,” Arzneimittel-Forschung/Drug Research, vol. 47, no. 4, pp. 568–572, 1997. View at Google Scholar · View at Scopus
  18. H. Shay, S. A. Komarov, S. S. Fels, D. Meranze, M. Gruenstein, and H. Siplet, “A simple method for the uniform production of gastric ulceration in the rat,” Gastroenterology, vol. 5, pp. 43–61, 1945. View at Google Scholar
  19. S. Rafatullah, M. Tariq, M. A. Al-Yahya, J. S. Mossa, and A. M. Ageel, “Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats,” Journal of Ethnopharmacology, vol. 29, no. 1, pp. 25–34, 1990. View at Google Scholar · View at Scopus
  20. T. K. Motawi, H. M. Abd Elgawad, and N. N. Shahin, “Gastroprotective effect of leptin in indomethacin-induced gastric injury,” Journal of Biomedical Science, vol. 15, no. 3, pp. 405–412, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Yoshikawa, Y. Naito, A. Kishi et al., “Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats,” Gut, vol. 34, no. 6, pp. 732–737, 1993. View at Google Scholar · View at Scopus
  22. L. H. Fermin Sanchez De Medina, J. Gálvez, J. A. Romero, and A. Zarzuelo, “Effect of Quercitrin on acute and chronic experimental colitis in the rat,” Journal of Pharmacology and Experimental Therapeutics, vol. 278, no. 2, pp. 771–779, 1996. View at Google Scholar · View at Scopus
  23. M. E. Crespo, J. Gálvez, T. Cruz, M. A. Ocete, and A. Zarzuelo, “Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS,” Planta Medica, vol. 65, no. 7, pp. 651–653, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. A. N. García-Argáez, T. O. Ramírez Apan, H. P. Delgado, G. Velázquez, and M. Martínez-Vázquez, “Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model,” Planta Medica, vol. 66, no. 3, pp. 279–281, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Cruz, J. Gálvez, E. Crespo, M. A. Ocete, and A. Zarzuelo, “Effects of Silymarin on the acute stage of the trinitrobenzenesulphonic acid model of rat colitis,” Planta Medica, vol. 67, no. 1, pp. 94–96, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. L. C. Di Stasi, D. Camuesco, A. Nieto, W. Vilegas, A. Zarzuelo, and J. Galvez, “Intestinal anti-inflammatory activity of paepalantine, an isocoumarin isolated from the capitula of Paepalanthus bromelioides, in the trinitrobenzenesulphonic acid model of rat colitis,” Planta Medica, vol. 70, no. 4, pp. 315–320, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Siegmund, S. Haas, A. Schneider, and M. V. Singer, “Animal models in gastrointestinal alcohol research—a short appraisal of the different models and their results,” Bailliere's Best Practice and Research in Clinical Gastroenterology, vol. 17, no. 4, pp. 519–542, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. P. A. Bafna and R. Balaraman, “Anti-ulcer and antioxidant activity of DHC-1, a herbal formulation,” Journal of Ethnopharmacology, vol. 90, no. 1, pp. 123–127, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Al-Howiriny, A. Alsheikh, S. Alqasoumi, M. Al-Yahya, K. ElTahir, and S. Rafatullah, “Protective effect of Origanum majorana L. “Marjoram” on various models of gastric mucosal injury in rats,” American Journal of Chinese Medicine, vol. 37, no. 3, pp. 531–545, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Szabo and P. Vattay, “Experimental gastric and duodenal ulcers: advances in Pathogenesis,” Gastroenterology Clinics of North America, vol. 19, no. 1, pp. 67–85, 1990. View at Google Scholar · View at Scopus
  31. A. S. Salim, “Sulfhydryl-containing agents: new approach to the problem of refractory peptic ulceration,” Pharmacology, vol. 46, pp. 281–288, 1993. View at Google Scholar
  32. J. R. Avila, C. Alarcón De La Lastra, M. J. Martín et al., “Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats,” Inflammation Research, vol. 45, no. 2, pp. 83–88, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Belley, K. Keller, M. Göettke, and K. Chadee, “Intestinal mucins in colonization and host defense against pathogens,” The American Journal of Tropical Medicine and Hygiene, vol. 60, no. 4, pp. 10–15, 1999. View at Google Scholar · View at Scopus
  34. D. Banerjee, S. A. Hassarajani, B. Maity, G. Narayan, S. K. Bandyopadhyay, and S. Chattopadhyay, “Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action,” Food and Function, vol. 1, no. 3, pp. 284–293, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Cadirci, H. Suleyman, H. Aksoy et al., “Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats,” Chemico-Biological Interactions, vol. 170, no. 1, pp. 40–48, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Aviello, J. M. Canadanovic-Brunet, N. Milic et al., “Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa,” PLoS One, vol. 6, no. 5, Article ID e19628, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Y. Li, H. D. Xu, B. T. Zhao, H. I. Chang, and H. I. Rhee, “Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats,” Alcohol, vol. 42, no. 8, pp. 683–687, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Petersson, M. Phillipson, E. Å. Jansson, A. Patzak, J. O. Lundberg, and L. Holm, “Dietary nitrate increases gastric mucosal blood flow and mucosal defense,” American Journal of Physiology, vol. 292, no. 3, pp. G718–G724, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. R. I. Morimoto and M. Gabriella Santoro, “Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection,” Nature Biotechnology, vol. 16, no. 9, pp. 833–838, 1998. View at Google Scholar · View at Scopus
  40. D. A. Campos, A. F. De Lima, S. R. L. Ribeiro et al., “Gastroprotective effect of a flavone from Lonchocarpus araripensis Benth. (Leguminosae) and the possible mechanism,” Journal of Pharmacy and Pharmacology, vol. 60, no. 3, pp. 391–397, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. K. Gyires, K. Müllner, S. Fürst, and A. Z. Rónai, “Alpha-2 adrenergic and opioid receptor-mediated gastroprotection,” Journal of Physiology Paris, vol. 94, no. 2, pp. 117–121, 2000. View at Publisher · View at Google Scholar · View at Scopus