Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect

Table 4

Effects of cimetidine (100 mg/kg) or epicatechin (50 mg/kg) on gastric juice parameters in rats (𝑛=7) with pyloric ligation. The results are expressed as the mean ± SEM and analyzed by ANOVA followed by Dunnett’s test. *𝑃<0.05 and **𝑃<0.01 compared to the vehicle group.

Route	Treatment	Gastric juice volume (mL)	[H^+] mequiv/mL/4 h
Oral	Vehicle	1.22±0.80	8.03±1.28
	Cimetidine	1.17±0.36	2.49 ± 0.47**
	Epicatechin	1.80±0.55	4.56 ± 0.56*
Intraduodenal	Vehicle	3.45±0.37	7.82±0.45
	Cimetidine	2.08 ± 0.16**	4.20 ± 0.63**
	Epicatechin	1.82 ± 0.15**	7.64±1.29