Evidence-Based Complementary and Alternative Medicine

Review Article

Chinese Medicine Shenfu Injection for Heart Failure: A Systematic Review and Meta-Analysis

Table 1

Characters of including trials.


Author Name	Inpatient (Y/N)	Course	Experiment group	Control group	NYHA classification	Disease duration	Followup (month)

Bao and Yu [61]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Chen [55]	Unclear	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Chen and Liu [14]	Y	60 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt plus metoprolol 6.25 mg, bid, po	Conventional medicine treatment plus metoprolol 6.25 mg, bid,po	II-III	1–15 y	No
Chen and Li [51]	Y	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt plus sodium nitroprusside 50 mg, iv.gtt	Conventional medicine treatment plus sodium nitroprusside 50 mg, iv.gtt	IV	Unclear	No
Chen et al. [52]	Y	15 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	4.5 y on average	No
Chen et al. [56]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	1.5 month–8 y	No
Cui [86]	Unclear	10 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Digoxigenin 0.25 mg	II-III	2–7 y	No
Deng and Tang [15]	Y	14 d	Conventional medicine treatment plus SFI 20–40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Di [67]	Unclear	Unclear	Conventional medicine treatment plus SFI 40 mL, bid, iv.gtt	Conventional medicine treatment	II–IV	3–17 y	No
Dou [97]	Unclear	10 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	y	No
Fan [60]	Y	21 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Metoprolol 12.5 mg, bid, po, +captopril 12.5 mg, tid, po	II–IV	Unclear	No
Fan et al. [101]	Unclear	14 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Geng et al. [27]	Both	12 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	0.5–9 y	No
Gu et al. [69]	Y	14 d	Conventional medicine treatment plus SFI 100 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	1.5–12 y	No
Guo et al. [49]	Unclear	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Guo et al. [23]	N	7 d	Conventional medicine treatment plus SFI 20 mL, iv + 50 mL, qd, iv.gtt plus non invasive positive pressure ventilation	Conventional medicine treatment plus non invasive positive pressure ventilation	Unclear	Unclear	No
Guo et al. [102]	Y	7 d	Conventional medicine treatment plus SFI 40–60 mL, qd, iv.gtt plus invasive respiratory support	Conventional medicine treatment plus invasive respiratory support	IV	Unclear	No
Han and Li [36]	Y	15 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	y	No
He [70]	Unclear	14 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	1–14 y	No
He [98]	Unclear	7–20 d/10–30 d	Conventional medicine treatment plus SFI 20–40 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	3–16 y	No
Hong [44]	Unclear	14 d	Conventional medicine treatment plus SFI 80 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Hou and Hong [17]	Unclear	7 d	Conventional medicine treatment plus SFI 60–100 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Huang [13]	Unclear	7 d	Conventional medicine treatment plus SFI 20 mL iv + 40 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Huang [53]	Y	14 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Huang et al. [24]	N	Unclear	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt plus sodium nitroprusside 50 mg, iv.gtt	Conventional medicine treatment plus sodium nitroprusside 50 mg, iv.gtt	Unclear	Unclear	No
Jia and Yang [71]	Y	20 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Jian and Chen [88]	Unclear	14 d	Conventional medicine treatment plus SFI 60–80 mL, bid, iv.gtt	Conventional medicine treatment	III-IV	6.5 y on average	No
Jiang [62]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Jin and Guo [95]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Ju [37]	Unclear	14 d	Conventional medicine treatment plus SFI 30 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Lei and Li [92]	Y	7–10 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Lei et al. [12]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	1–18 y	3
Li et al. [9]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	1–20 y	3
Li et al. [72]	Y	15 d	Conventional medicine treatment plus SFI 30 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	5–26 y	No
Li [96]	Unclear	15 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Li et al. [73]	Unclear	15 d	Conventional medicine treatment plus SFI 100 mL, qd, iv.gtt plus sodium nitroprusside 50 mg	Conventional medicine treatment plus sodium nitroprusside 50 mg	IV	l–25 y	No
Li [93]	Unclear	10 d	Conventional medicine treatment plus SFI 1 mL/kg body weight, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Liu [75]	Y	21 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Liu and Sun [18]	Unclear	7 d	Conventional medicine treatment plus SFI 100 mL, qd, iv.gtt	Conventional medicine treatment	Unclear	Unclear	No
Liu and Chan [50]	Unclear	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Liu et al. [20]	Y	28 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	9 month–14 y	No
Liu [74]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Liu et al. [94]	Unclear	14 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Lv [57]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Luo et al. [76]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment plus sodium nitroprusside	III-IV	Unclear	No
Luo et al. [38]	Unclear	10 d/m 6 months	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	>3 months	6
Ma et al. [48]	Unclear	20 d	Conventional medicine treatment plus SFI 30–40 mL, qd, iv.gtt	Conventional medicine treatment	II-III	Unclear	No
Ma and Huang [99]	Y	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Ma [77]	Unclear	15 d	Conventional medicine treatment plus SFI 20 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Pan et al. [89]	Y	14 d	Conventional medicine treatment plus SFI 100 mL, qd, iv.gtt	Conventional medicine treatment plus dobutamine hydrochloride 40 ng, qd, iv.gtt	II–IV	2.5 month–11 y	No
Qiu [103]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Ru [46]	Unclear	10 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Shang [78]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Song [106]	Y	15 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II-III	Unclear	No
Song et al. [10]	Y	15 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Su [90]	Y	14 d	Conventional medicine treatment plus SFI 100 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Tan et al. [58]	Unclear	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Tian and Gong [16]	Y	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	2–20 y	No
Tian [80]	Y	15 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	>7 months	No
Tu and Yang [63]	Y	14 d	Conventional medicine treatment plus SFI 80 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Tu et al. [32]	Unclear	14 d	Conventional medicine treatment plus SFI 100 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
G. L. Wang and J. Wang [104]	Y	15 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	2.5–16 y	No
Wang [100]	Y	14 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	Unclear	y	No
Wang [39]	Unclear	15 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Wang [28]	Both	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	0.6–7 y	No
Wang and Ye [87]	Y	10 d	Conventional medicine treatment plus SFI 40–100 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	14.2 y mean	No
Wang et al. [81]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	IV	3–10 y	No
Wu and Duan [45]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II-III	Unclear	No
Wu and Wang [64]	Y	14 d	Conventional medicine treatment plus SFI 100 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Wu et al. [40]	Unclear	10 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Yang and Wu [82]	Y	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Yang et al. [54]	Y	15 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	5.1 y	No
Yao and Lu [65]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Yin [83]	Y	14 d	Conventional medicine treatment plus SFI 40 mL, qd, iv	Conventional medicine treatment	II–IV	0.5–12 y	No
Yu et al. [84]	Unclear	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Yu [66]	Unclear	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Zhan and Yang [47]	Unclear	20 d	Conventional medicine treatment plus SFI 40 mL, qd, iv.gtt plus metoprolol. 25 mg–75 mg, bid po	Conventional medicine treatment plus metoprolol. 25 mg–75 mg, bid, po	II-III	Unclear	12
Zhang [79]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	3–15 y	No
Zhang et al. [85]	Y	20 d	Conventional medicine treatment plus SFI 30 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Zhang [42]	Y	21 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II-III	Unclear	No
Zhang and Pan [30]	Both	14 d	Conventional medicine treatment plus SFI 40–60 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	2–16 y	No
Zhang [29]	Both	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Zhang [43]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Zhao et al. [11]	Y	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment plus isoket 10 mg,qd,iv.gtt	II–IV	1–20 y	3
Zhao [91]	Y	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	Unclear	Unclear	No
Zhou [59]	Y	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	IV	3–15 y	No
Zhou [19]	Y	10 d	Conventional medicine treatment plus SFI 80 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Zhou et al. [31]	Both	14 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Zhu and Ma [105]	Y	15 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	III-IV	Unclear	No
Zi and Li [41]	Y	14 d	Conventional medicine treatment plus SFI 40–100 mL, qd, iv or iv.gtt	Conventional medicine treatment plus dobutamine hydrochloride 50–100 mg	II–IV	Unclear	No
Guo et al. [22]	N	14 d	Conventional medicine treatment plus SFI 60–100 mL, bid, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No
Mo and Zhao [25]	N	7 d	Conventional medicine treatment plus SFI 60–100 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	1–7 d	No
Song and Zhang [33]	Y	10 d	Conventional medicine treatment plus SFI 40–60 mL, qd, iv.gtt	Conventional medicine treatment plus dobutamine hydrochloride 40 mg	II–IV	Unclear	No
Zeng et al. [34]	Y	7 d	Conventional medicine treatment plus SFI 50 mL, qd, iv.gtt	Conventional medicine treatment	IV	Unclear	No
Zeng [26]	N	10 d	Conventional medicine treatment plus SFI 60–100 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	1–72 h	No
Zhang [35]	Y	14 d	Conventional medicine treatment plus SFI 60 mL, qd, iv.gtt	Conventional medicine treatment	II–IV	Unclear	No

Conventional medicine treatment includes sitting up position, supplemental oxygen, vasodilator such as nitroglycerine, diuretics such as furosemide, and cardiotonic agents such as lanatoside C, ACE inhibitors, and β-blockers.