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| Study | Method | N (M : F) | Mean age | Interventions | Outcomes |
|
| Zhao 2007 [19] | RCT, not blinded
Duration: 2 W | 78 (54 : 24) | 62.8 | (1) Isosorbide mononitrate 40 mg
(2) SS 40 mg | (1) clinical symptom improvement, (2) ECG, (3) frequency, duration and intervals of angina attacks |
| Yan et al. 2009 [20] | RCT, not blinded
Duration: 4 W | 94 (53 : 41) | 52 | (1) Routine (Aspirin 300 mg–100 mg qd, Enoxaparin, Elantan 50 mg, Betaloc 100 mg)
(2) Routine + SS 60 mg | (1) clinical symptom improvement, (2) ECG, (3) FIB, (4) D-dimer |
| Wang and Hou 2010 [21] | RCT, not blinded
Duration: 2 W | 100 (65 : 35) | 62 | (1) Routine (Aspirin, Nitrates, Calcium antagonists, Ozagrel)
(2) Routine + SS 40 mg | (1) clinical symptom improvement, (2) ECG |
| Yang et al. 2010 [13, 22] | RCT, not blinded
Duration: 1 W | 64 (35 : 39) | 59 | (1) Routine (Aspirin 100 mg qd, Isosorbide mononitrate 20 mg bid, Metoprolol 25 mg bid)
(2) Routine + SS 60 mg | (1) clinical symptom improvement, (2) ECG, (3) C-reaction protein, (4)IL-6, (5) plasma viscosity, (6) FIB |
| Ge et al. 2010 [23] | RCT, not blinded
Duration: 15 D | 60 (39 : 21) | 58 | (1) Routine (Nitrates, Betaloc, anticoagulant and antiplatelet aggregation medication, ACEI, Statins)
(2) Routine + SS 60 mg | (1) clinical symptom improvement, (2) ECG, (3) TC, TG, LDL-C, HDL-C |
| Ge and Zhu 2009 [24] | RCT, not blinded
Duration: 2 W | 48 (32 : 16) | 40–80Range | (1) Routine (Aspirin, Betaloc, ACEI, Calcium antagonists, Isosorbide mononitrate, antiplatelet agents, Trimetazidine)
(2) Routine + SS 50 mg | (1) clinical symptom improvement. |
| Hu et al. 2009 [25] | RCT, not blinded
Duration: 2 W | 148 | 60 | (1) Routine (Statins, ARB, ACEI, Nitrates, Aspirin, LMWH, Betaloc)
(2) Routine + SS 40 mg | (1) clinical symptom improvement, (2) ECG. |
| Pei and Chen 2009 [26] | RCT, not blinded
Duration: 2 W | 71 (48 : 23) | 65 | (1) Routine (Aspirin, Clopidogrel, LMWH, Nitrates, Betaloc, Statins, nondihydropyridine calcium antagonists)
(2) Routine + SS 40 mg | (1) clinical symptom improvement, (2) plasma viscosity, (3) blood viscosity at high/low shear stress, (4) hematocrit. |
| Zuo and Hou 2009 [27] | RCT, not blinded
Duration: 2 W | 83 (58 : 25) | 72 | (1) Routine (Aspirin, Betaloc, Nitrates, Statins, LMWH)
(2) Routine + SS 40 mg | (1) clinical symptom improvement, (2) length of angina from attacking to alleviating, (3) length of angina from attacking to vanishing, (4) times of myocardial ischemia onset. |
| Song 2008 [28] | RCT, not blinded
Duration: 2 W | 105 | 72 | (1) Routine (Aspirin, Simvastatin, Betaloc, Nitrates, Diltiazem, ARB, ACEI)
(2) Routine + SS 60 mg | (1) clinical symptom improvement. |
| Xu and Su 2008 [29] | RCT, not blinded
Duration: 1 W | 74 (40 : 30) | 45–78Range | (1) Routine (Fluvastatin, Aspirin, Betaloc, LMWH)
(2) Routine + SS 80 mg | (1) C-reaction protein, (2) IL-6, (3) P-selectin, (4) PAI-1 |
| Huang et al. 2008 [30] | RCT, not blinded
Duration: 2 W | 220 (140 : 80) | 62 | (1) Routine (LMWH, Betaloc, Isosorbide mononitrate, calcium antagonists, Statins, Aspirin)
(2) Routine + SS 60 mg | (1) clinical symptom improvement, (2) ECG, (3) plasma/whole blood viscosity, (4) systolic/diastolic blood pressure, (5) heart rate, (6) hematocrit, (7) Platelet aggregation, (8) FIB. |
| Li et al. 2008 [31] | RCT, not blinded
Duration: 2 W | 125 (80 : 45) | 62.41 | (1) Routine (ACEI, vasodilator, antiplatelet agents, anticoagulants)
(2) Routine + SS 60 mg | (1) NO, (2) FMD, (3) ET. |
| Hua et al. 2007 [32] | RCT, not blinded
Duration: 2 W | 112 (69 : 43) | 60 | (1) Routine (Aspirin, LMWH, Betaloc, Nitroglycerin, ACEI, Isosorbide mononitrate)
(2) Routine + SS 80 mg | (1) clinical symptom improvement, (2) ECG, (3) plasma viscosity, (4) whole blood viscosity,
(5) erythrocyte aggregation, (6) morality, (7) FIB. |
| Wang et al. 2007 [33] | RCT, not blinded
Duration: 2 W | 50 (28 : 22) | 48.5 | (1) Routine (Betaloc, Isosorbide mononitrate, Diltiazem, Aspirin)
(2) Routine + SS 50 mg | (1) clinical symptom improvement, (2) ECG, (3) D-dimer, (4) C-reaction protein, (5) plasma viscosity, (6) erythrocyte aggregation, (7) hematocrit. |
| Ma et al. 2007 [34] | RCT, not blinded
Duration: 2 W | 59 (37 : 22) | 62.7 | (1) Routine (Betaloc, Aspirin, ACEI, Isosorbide mononitrate, calcium antagonists, anticoagulants,)
(2) Routine + SS 40 mg | (1) clinical symptom improvement, (2) ECG, (3) morality. |
| X. G. Zhang and Y. M. Zhang 2006 [35] | RCT, not blinded
Duration: 4 W | 60 (33 : 27) | 62 | (1) Routine (antiplatelet agents, Nitrates, Betaloc, ACEI, Diuretics)
(2) Routine + SS 60 mg | (1) clinical symptom improvement, (2) ECG, (3) systolic/diastolic blood pressure, (4) heart rate, (5) frequency and duration of angina attacks, (6) Premature ventricular contractions in 24 hours. |
| Zhang et al. 2006 [36] | RCT, single blinded
Duration: 2 W | 52 | — | (1) Routine (Nitrates, Betaloc, Aspirin)
(2) Routine + SS 80 mg | (1) clinical symptom improvement, (2) ECG. |
| Liu and Yang 2010 [37] | RCT, not blinded
Duration: 2 W | 100 (61 : 49) | 65 | (1) Routine (LMWH 6000 U q12h, Nitrates, Simvastatin 20 mg qn, Betaloc, ACEI, Aspirin)
(2) Routine + SS 50 mg | (1) clinical symptom improvement. |
| Yang and Cai 2009 [38] | RCT, not blinded
Duration: 4 W | 64 (32 : 32) | 49.5 | (1) Routine (Captopril 25 mg qd, Betaloc 25 mg bid, Isosorbide mononitrate 40 rag qd, Aspirin 0.1 g pd, Simvastatin 25 rag, qn)
(2) Routine + SS 60 mg | (1) clinical symptom improvement, (2) ECG, (3) frequency and duration of angina attacks. |
| Bai and Ding 2007 [39] | RCT, not blinded
Duration: 4 W | 80 (42 : 38) | 61 | (1) Routine (Nitrates, Betaloc, ACEI, antiplatelet agents, LMWH)
(2) Routine + SS 80 mg | (1) clinical symptom improvement, (2) ECG. |
| Fang and Wang 2007 [40] | RCT, not blinded
Duration: 10 D | 120 (54 : 66) | 74 | (1) Routine (LMWH 5000 U, Nitroglycerin 10 mg)
(2) Routine + SS 60 mg | (1) clinical symptom improvement. |
| Jiang 2004 [41] | RCT, not blinded
Duration: 3 W | 156 (82 : 74) | 60.9 | (1) Routine (ACEI, Betaloc)
(2) Routine + SS 40 mg |
(1) clinical symptom improvement, (2) C-reaction protein, (3) times of angina attacks daily. |
| Qi and Qu 2008 [42] | RCT, not blinded
Duration: 2 W | 68 (38 : 30) | 63 | (1) Routine (Nitrates, Aspirin)
(2) Routine + SS 60 mg | (1) frequency of angina attacks, (2) duration of angina attacks, (3) TC, TG, HDL, LDL. |
| Han and Wang 2011 [43] | RCT, not blinded
Duration: 2W | 186 (94 : 92) | 55 | (1) Routine (nitroglycerin 20 mg)
(2) Routine + SS 60 mg | (1) clinical symptom improvement. |
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