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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 726025, 15 pages
Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
1Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany
2Cytometry Core Facility, Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany
Received 10 July 2012; Accepted 7 September 2012
Academic Editor: Ke Liu
Copyright © 2012 Benjamin Wiench et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [26 citations]
The following is the list of published articles that have cited the current article.
- Heyong Wang, Chunlian Wu, Shengbang Wan, Huijun Zhang, Songwen Zhou, and Gentao Liu, “Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway,” Toxicology, vol. 308, pp. 104–112, 2013.
- Benjamin Wiench, Yet-Ran Chen, Malte Paulsen, Rebecca Hamm, Sven Schröder, Ning-Sun Yang, and Thomas Efferth, “Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–11, 2013.
- I. Andujar, M. C. Recio, R. M. Giner, and J. L. Rios, “Traditional Chinese Medicine Remedy to Jury: The Pharmacological Basis for the Use of Shikonin as an Anticancer Therapy,” Current Medicinal Chemistry, vol. 20, no. 23, pp. 2892–2898, 2013.
- Shuqing Shi, and Haimei Cao, “Shikonin promotes autophagy in BXPC-3 human pancreatic cancer cells through the PI3K/Akt signaling pathway,” Oncology Letters, vol. 8, no. 3, pp. 1087–1089, 2014.
- Su-Tze Chou, Hui-Chiu Lin, Mei-Yu Chuang, and Tsai-Hsin Chiu, “ Treatment with C aulerpa Microphysa Pepsin-Digested Extract Induces Apoptosis in Murine Leukemia WEHI-3 Cells ,” Journal of Food Biochemistry, vol. 38, no. 5, pp. 469–479, 2014.
- Shahla Karim Baloch†, Li-Jun Ling†, Han-Yue Qiu, Lin Ma, Hong-Yan Lin, Shou-Cheng Huang, Jin-Liang Qi, Xiao-Ming Wang, Gui-Hua Lu, and Yong-Hua Yang, “Synthesis and biological evaluation of novel shikonin ester derivatives as potential anti-cancer agents,” RSC Advances, vol. 4, no. 67, pp. 35588, 2014.
- Seo-Young Kwak, Youn Kyoung Jeong, Bu-Yeon Kim, Ji Young Lee, Hyun-Joo Ahn, Jae-Hoon Jeong, Mi-Sook Kim, Joon Kim, and Young-Hoon Han, “beta,beta-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species,” Oncology Letters, vol. 7, no. 6, pp. 1812–1818, 2014.
- Sun-Joong Kim, Jee Min Kim, So Hee Shim, and Hyo Ihl Chang, “Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression,” Journal of Ethnopharmacology, vol. 151, no. 3, pp. 1064–1071, 2014.
- Ravichandran Senthilkumar, Bao-An Chen, Xiao-Hui Cai, and Rong Fu, “Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines,” Chinese Journal of Natural Medicines, vol. 12, no. 12, pp. 881–894, 2014.
- Ravichandran Senthilkumar, Chen Bao-An, Cai Xiao-Hui, and Fu Rong, “Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines,” Chinese Journal Of Natural Medicines, vol. 12, no. 12, pp. 881–894, 2014.
- Maen Zeino, Malte S. Paulsen, Martin Zehl, Ernst Urban, Brigitte Kopp, and Thomas Efferth, “Identification of New P-Glycoprotein Inhibitors Derived from Cardiotonic Steroids,” Biochemical Pharmacology, 2014.
- Yoshikatsu Ogawa, Yasuhiro Kawano, Yoshimitsu Yamazaki, and Yoshiaki Onishi, “Shikonin shortens the circadian period: Possible involvement of Top2 inhibition,” Biochemical and Biophysical Research Communications, vol. 443, no. 1, pp. 339–343, 2014.
- Efthymia-Iliana Matthaiou, Jaleh Barar, Raphael Sandaltzopoulos, Chunsheng Li, George Coukos, and Yadollah Omidi, “Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer,” International Journal of Nanomedicine, vol. 9, pp. 1855–1870, 2014.
- Zhuanhua Wang, Shanshan Li, Rong Ren, Jiao Li, and Xiaodong Cui, “Recombinant Buckwheat Trypsin Inhibitor Induces Mitophagy by Directly Targeting Mitochondria and Causes Mitochondrial Dysfunction in Hep G2 Cells,” Journal of Agricultural and Food Chemistry, pp. 150826160622003, 2015.
- Rajapaksha Gedara Prasad Tharanga Jayasooriya, Kyoung-Tae Lee, Yung Hyun Choi, Sung-Kwon Moon, Wun-Jae Kim, and Gi-Young Kim, “Antagonistic effects of acetylshikonin on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1,” In Vitro Cellular & Developmental Biology - Animal, 2015.
- So Young Gwon, Won Hee Choi, Da Hye Lee, Ji Yun Ahn, Chang Hwa Jung, BoKyung Moon, and Tae Youl Ha, “Shikonin protects against obesity through the modulation of adipogenesis, lipogenesis, and β-oxidation in vivo,” Journal of Functional Foods, vol. 16, pp. 484–493, 2015.
- Ravi Thakur, Rachana Trivedi, Namrata Rastogi, Manisha Singh, and Durga Prasad Mishra, “Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer,” Scientific Reports, vol. 5, pp. 10194, 2015.
- Rishi Kumar Gara, Vikas Kumar Srivastava, Shivali Duggal, Jaspreet Kaur Bagga, Mlb Bhatt, Sabyasachi Sanyal, and Durga Prasad Mishra, “Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway,” Journal of Biomedical Science, vol. 22, no. 1, 2015.
- Qiaoli Zhao, Nadine Kretschmer, Rudolf Bauer, and Thomas Efferth, “Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib,” International Journal of Cancer, 2015.
- Dan Qu, Yu Chen, Xiao-Man Xu, Meng Zhang, Yi Zhang, and Sheng-Qi Li, “Cbl-b-regulated extracellular signal-regulated kinase signaling is involved in the shikonin-induced apoptosis of lung cancer cells inï¿½vitro,” Experimental and Therapeutic Medicine, 2015.
- Zahra Shahsavari, Fatemeh Karami-Tehrani, Siamak Salami, and Mehran Ghasemzadeh, “RIP1K and RIP3K provoked by shikonin induce cell cycle arrest in the triple negative breast cancer cell line, MDA-MB-468: necroptosis as a desperate programmed suicide pathway,” Tumor Biology, 2015.
- Yun-Ji Jeung, Han-Gyeul Kim, Jiwon Ahn, Ho-Joon Lee, Sae-Bhom Lee, Misun Won, Cho-Rock Jung, Joo-Young Im, Bo-Kyung Kim, Seung-Kiel Park, Myung Jin Son, and Kyung-Sook Chung, “Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300,” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016.
- Paramasivan Poornima, Jothi Dinesh Kumar, Qiaoli Zhao, Martina Blunder, and Thomas Efferth, “Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature,” Pharmacological Research, 2016.
- Xuxia Tang, Chen Zhang, Jiongzhou Wei, Yuting Fang, Rongxiang Zhao, and Jianxin Yu, “Apoptosis is induced by shikonin through the mitochondrial signaling pathway,” Molecular Medicine Reports, vol. 13, no. 4, pp. 3668–3674, 2016.
- Khan Behlol Ayaz Ahmed, Santanu Kar Mahapatra, Mamilla R. Charan Raja, Shankar Subramaniam, Megarajan Sengan, Narendran Rajendran, Sandeep Kumar Das, Kuntal Haldar, Somenath Roy, Aravind Sivasubramanian, and Veerappan Anbazhagan, “Jacalin-capped silver nanoparticles minimize the dosage use of the anticancer drug, shikonin derivatives, against human chronic myeloid leukemia,” Rsc Advances, vol. 6, no. 23, pp. 18980–18989, 2016.
- Zhangfeng Zhong, William W. Qiang, Wen Tan, Haotian Zhang, Shengpeng Wang, Chunming Wang, Wenan Qiang, and Yitao Wang, “Chinese Herbs Interfering with Cancer Reprogramming Metabolism,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–10, 2016.