Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Table 2

Quantitative summary of gross observations in MIA-induced osteoarthritic rats treated with GCSB-5.

		Control	MIA
			Vehicle	GCSB-5 (mg/kg)		Diclofenac
				300	600	5 mg/kg
Swelling
No change	0	10/10	0/10	1/10	1/10	0/10
Mild	1	0/10	3/10	8/10	6/10	8/10
Severe	2	0/10	7/10	1/10	3/10	2/10
Average score		0.0±0.0	1.7±0.2^a	1.0±0.2^a,b	1.2±0.2^a	1.2±0.1^a
Limping
No change	0	10/10	0/10	6/10	5/10	5/10
Mild	1	0/10	7/10	4/10	5/10	5/10
Severe	2	0/10	3/10	0/10	0/10	0/10
Average score		0.0±0.0	1.3±0.2^a	0.4±0.2^c	0.5±0.2^c	0.5±0.2^c

GCSB-5 or diclofenac was treated daily for 14 days after 2 weeks of OA induction by intra-articular injection of MIA.
^aDenotes significant differences (𝑃<0.01) versus the control group.
^b,cDenote significant differences (𝑃<0.05,𝑃<0.01) versus the vehicle-treated MIA group.