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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 743107, 10 pages
Research Article

Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus

1Division of Nephrology, Department of Medicine, Chi-Mei Medical Center, Tainan 71004, Taiwan
2Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan 71703, Taiwan
3Department of Sport Management, College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan
4Department of Food Nutrition, Chung Hwa University of Medical Technology, Tainan 71703, Taiwan
5Institute of Biotechnology, Southern Taiwan University, Tainan 71005, Taiwan
6Institute of Biomedical Engineering, Southern Taiwan University, Tainan 71005, Taiwan
7Department of Family Medicine, Chi-Mei Medical Center, Tainan 71004, Taiwan
8Department of Nephrology, Sin-Lau Hospital, Tainan 70142, Taiwan
9Department of Pharmacy, Wei Gong Memorial Hospital, Miaoli 35159, Taiwan

Received 10 June 2011; Accepted 7 December 2011

Academic Editor: E. Yesilada

Copyright © 2012 Wei-Chih Kan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetes mellitus is the most common chronic disease in the world, and a wide range of drugs, including Chinese herbs, have been evaluated for the treatment of associated metabolic disorders. This study investigated the potential hypoglycemic and renoprotective effects of an extract from the solid-state fermented mycelium of Cordyceps sinensis (CS). We employed the KK/HIJ diabetic mouse model, in which the mice were provided with a high-fat diet for 8 weeks to induce hyperglycemia, followed by the administration of CS or rosiglitazone for 4 consecutive weeks. Several parameters were evaluated, including changes in body weight, plasma lipid profiles, oral glucose tolerance tests, insulin tolerance tests, and plasma insulin concentrations. Our results show that the CS extract significantly elevated HDL/LDL ratios at 4 weeks and decreased body weight gain at 8 weeks. Interestingly, CS treatment did not lead to obvious improvements in hyperglycemia or resistance to insulin, while in vitro MTT assays indicated that CS protects pancreatic beta cells against the toxic effects of STZ. CS also enhanced renal NKA activity and reduced the accumulation of mesangial matrix and collagen deposition. In conclusion, CS extract can potentially preserve β-cell function and offer renoprotection, which may afford a promising therapy for DM.