Flavonoid Myricetin Modulates
Receptor Activity through Activation of Channels and CaMK-II Pathway
CaMK-II inhibitor KN-62 blocks the effect of myricetin on receptor in PVN neurons. (a) and (b) Zolpidem increases the half-decay time of mIPSC in the PVN neurons (, ), and this effect is totally blocked by BZ site antagonist Flumazenil. (c), Flumazenil cannot block the effect of myricetin on the decay time of mIPSC (, ). (d) The CaMK-II inhibitor KN-62 (15 μM) could completely prevent the increase of decay time induced by myricetin ().
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