Pharmacokinetics of Ganoderic Acids A and F after Oral Administration of Ling Zhi Preparation in Healthy Male Volunteers

Table 2

Pharmacokinetic parameters of ganoderic acids A and F after a single oral administration of MG2FB-WE under a fasting or fed condition.^†

Parameters	Ganoderic acid A		Ganoderic acid F
	Fasting condition	Fed condition	Fasting condition	Fed condition
𝐶𝑚𝑎𝑥 (ng/mL)	10.99±4.02 **	3.84±1.56	2.57±0.91	ND
𝑇𝑚𝑎𝑥 (h)	0.54±0.18 *	1.67±0.88	0.52±0.13	ND
𝑡1/2 (h)	0.62±0.17 *	1.34±0.65	0.48±0.22	ND
AUC0-8 (ng·h/mL)	9.58±4.08	8.75±5.32	1.81±0.76	ND
AUC0-∞ (ng·h/mL)	10.53±4.32	11.02±5.54	2.42±0.93	ND

^† Data represents mean ± SD.
* 𝑃<0.01, **𝑃<0.001 denote statistically significant as compared to a fed condition according to paired Student’s t-test.
ND: cannot be determined because the plasma ganoderic acid F concentrations at any time points were below the LLOQ in most of the enrolled subjects.