NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity
Figure 1
NBM-HD-1 inhibition of cancer cells growth. (a) Structures of propolin G, NBM-HD-1-1, NBM-HD-1-2, and NBM-HD-1. (b) Cells growth inhibition of NBM-HD-1 after treatment with various concentrations in rat C6 glioma cells, human MCF-7 breast cancer cells, and human MDA-MB-231 breast cancer cells for 48 h. (c) Human MDA-MB-231 breast cancer cells ( per well) were cultured in 6-well plates and incubated for 14 h, then treated with a fixed concentration of 17.0 μM for 1–3 days. Data are shown as the mean ± SD. **; *** versus the control. All these tests were performed in three independent experiments. A representative experiment of the three replicates is shown.
