Activation of Spinal 𝜶2-Adrenoceptors Using Diluted Bee Venom Stimulation Reduces Cold Allodynia in Neuropathic Pain Rats

Figure 4

Effect of repetitive DBV treatment on cold allodynia. A graph illustrating the effect of repetitive treatment with diluted bee venom (DBV) from 2 weeks after CCI on cold allodynia in neuropathic rats. The repetitive saline injection group (CCI: R-Sal) significantly increased the paw withdrawal frequency (PWF, %) to 13 days after repetitive saline injection (***𝑃<0.001 compared with the sham surgery animals, Sham: Naive). The repeated DBV-treated animals (CCI: R-DBV (0.25 mg)) also increased the PWF to day 7 compared with the sham surgery group (**𝑃<0.01 and ***𝑃<0.001) and reversed the PWF from 7 days compared with the saline-treated group animals (^### 𝑃<0.001).