Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats
Figure 2
Gross appearance of the gastric mucosa in rats. (a) Rats pretreated with 5 mL/kg CMC (normal control). No injuries to the gastric mucosa are seen. (b) Rats pretreated with 5 mL/kg CMC (ulcer control). Severe injuries are seen in the gastric mucosa. HCl/ethanol produced extensive visible hemorrhagic necrosis of gastric mucosa. (c) Rats pretreated with omeprazole (20 mg/kg). Injuries to the gastric mucosa are milder compared to the injuries seen in the ulcer control rats. (d). Rat pretreated with J. sambac extract (62.50 mg/kg). Moderate injuries are seen in the gastric mucosa. The extract reduces the formation of gastric lesions induced by acidified ethanol. (e). Rat pretreated with J. sambac extract (125 mg/kg). Moderate injuries are seen in the gastric mucosa. The extract reduces the formation of gastric lesions induced by acidified ethanol (f). Rat pretreated with J. sambac extract (250 mg/kg). Mild injuries are seen in the gastric mucosa. The extract reduces the formation of gastric lesions induced by acidified ethanol. (g) rats pretreated with 500 mg/kg of J. sambac extract. No injuries to the gastric mucosa are seen instead flattening of gastric mucosa is seen.
