In Vivo Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicine, “Shahakusan,” and Its Possible Mode of Action
Effect of SHS on the proliferation of influenza virus in the nasal cavity of upper respiratory tract infected mice. BALB/c mice were administered orally with water, SHS or oseltamivir from 7 days before to 4 days p.i. (−7 d to 4 d), one day before to 4 days p.i. (−1 d to 4 d), or 2 hours p.i. to 4 days p.i. (2 h to 4 d) as shown in Figure 2(a). The infectious virus titers in NLF of influenza virus infected mice were estimated at 5 day p.i. with plaque assay. Values represent means ± S.E. ().