The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker
Figure 4
Statistical bar graph of the effects of KCNQ openers, lamotrigine and linopirdine (0.05 mM) on the twitch duration (TD50) of the muscle induced by 9-AC (0.1 mM). Control: no chemical treatment; 9-AC: 9-AC treatment alone; Ret: retigabine (0.03 mM); Flu: flupirtine (0.03 mM); Flu-lino: flupirtine plus linopirdine; Lam: lamotrigine; Lam-lino: lamotrigine plus linopirdine. TD50: twitch duration at 50% of the amplitude. # as compared with 9-AC alone; * as compared with retigabine (ret) or flupirtine (flu); N.S: no significance.
