Research Article

The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker

Figure 6

The effects of retigabine, flupirtine, and lamotrigine on the firing frequency of repetitive action potentials induced by 9-AC (0.1 mM). A train of muscle action potentials was triggered by a depolarising current injection (20 nA, 200 msec) through the recording pipette. The effects of retigabine (0.03 mM), flupirtine (0.03 mM), and lamotrigine (0.03 mM) on the firing frequency of action potentials induced by 9-AC are shown in (a, b, and c), respectively. * as compared with 9-AC alone.
803082.fig.006