Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo

<table>Effects of terpinen-4-ol on viability and morphology of A549 and CL1-0 cells. (a) A549 and CL1-0 cells were seeded at 5 × 10<sup>4</sup> cells/well and then treated with the indicated concentrations of terpinen-4-ol for 24 hours following attachment. The cell viability was determined by the MTT assay. Each point on the graph represents the mean ± SD of triplicate tests. <svg height="17.825001" id="M4" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 21.375 17.825001" width="21.375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> value &lt;.05 compared with the untreated control group. (b) The morphology of A549 and CL1-0 cells treated with various concentrations of terpinen-4-ol for 24 hours were observed by phase-contrast microscopy and photographed (400×).</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo 