Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-𝜶 in High-Fat-Diet-Induced Obese Rats

Table 3

Results of histopathological findings in livers and epididymal adipocytes of HFD-fed rats receiving 12-weeks treatment with VBRB or fenofibrate.

Groups	Hepatic steatosis (0–4)	Average sizes of epididymal adipocytes (μm^2)
RCD-fed
Vehicle	0^b	3160.5 ± 230.3^b
HFD-fed
Vehicle	3.28 ± 0.56	5502.3 ± 210.9
VBRB (g kg^−1 per day)
0.3	2.64 ± 0.61	4480.2 ± 156.2^a
0.5	2.58 ± 0.74	4072.8 ± 181.3^a
1.0	2.23 ± 0.53	3501.2 ± 148.2^b
Fenofibrate (100 mg kg^−1 per day)	2.12 ± 0.39^a	3226.5 ± 174.6^b

The vehicle (distilled water) used to solve the tested medications was given at the same volume. Values (mean ± SD) were obtained from each group of 5 animals in each group during after 12 weeks of the experimental period. The size and number of epididymal adipocytes in a fixed area (1,000,000 μm²) were measured. ^a𝑃<.05 and ^b𝑃<.01 compared to the values of vehicle-treated HFD-fed rats in each group, respectively.