Anti-Inflammatory and Anticoagulative Effects of Paeonol on LPS-Induced Acute Lung Injury in Rats
Figure 1
Effects of paeonol on LPS-induced histopathological damage in rats. Histopathological damage developed 16 h after intratracheal administration of LPS (16 mg/kg). The alveolar spaces (*) are filled with a mixed mononuclear/neutrophilic infiltrate (▸), red blood cells (⇒), and protein exudation. The alveolar walls (→) are thickened and edematous. Note the presence of cellular debris and proteinaceous material in the air spaces in the lung tissue of the LPS-DMSO group (c) with 200x; (d) with 400x. No prominent neutrophil infiltration, red blood cells or protein exudates were seen in the PBS-DMSO group (a) and PBS-paeonol group (b). The infiltration of neutrophil, red blood cells and protein exudation was reduced in the LPS-paeonol-25 group (e) and LPS-paeonol-50 group (f).
