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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 837581, 10 pages
Research Article

Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model

1Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
3Department of Pharmacology, School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China
4Shanghai Anshan Experimental Middle School, Shanghai 200433, China
5The School of Pharmacy & Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Liverpool L3 3AF, UK

Received 9 November 2012; Revised 11 December 2012; Accepted 11 December 2012

Academic Editor: Ke Liu

Copyright © 2012 Hong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Wei Ma, Di-Di Wang, Li Li, Yu-Kuan Feng, Hong-Mei Gu, Gui-Ming Zhu, Jin-Hua Piao, Yu Yang, Xu Gao, and Peng-Xia Zhang, “Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells,” Oncology Reports, vol. 32, no. 1, pp. 293–301, 2014. View at Publisher · View at Google Scholar
  • Yunmin Lu, Meiying Zhu, Wei Chen, Li Yin, Jinshui Zhu, Niwei Chen, and Weixiong Chen, “Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways,” Pharmaceutical Biology, vol. 52, no. 6, pp. 789–795, 2014. View at Publisher · View at Google Scholar
  • Guo-Yin Zheng, Li-Ping Qu, Xiao-Qiang Yue, Wei Gu, Hong Zhang, and Hai-Liang Xin, “Portulacerebroside A induces apoptosis via activation of the mitochondrial death pathway in human liver cancer HCCLM3 cells,” Phytochemistry Letters, vol. 7, pp. 77–84, 2014. View at Publisher · View at Google Scholar
  • Jian-Yu Chen, Lei Zhang, Hong Zhang, Li Su, and Lu-Ping Qin, “Triggering of p38 MAPK and JNK Signaling is Important for Oleanolic Acid-Induced Apoptosis via the Mitochondrial Death Pathway in Hypertrophic Scar Fibroblasts,” Phytotherapy Research, vol. 28, no. 10, pp. 1468–1478, 2014. View at Publisher · View at Google Scholar
  • Mohammad M. Al-Qattan, Mervat M. Abd-Al Wahed, Khalid Hawary, Ahmed A. Alhumidi, and Medhat K. Shier, “Recombinant nAG (a Salamander-Derived Protein) Decreases the Formation of Hypertrophic Scarring in the Rabbit Ear Model,” BioMed Research International, vol. 2014, pp. 1–5, 2014. View at Publisher · View at Google Scholar
  • Jian-Rao Lu, Hai-Yan Han, Jie Chen, Chong-Xiang Xiong, Xin-Hua Wang, Jing Hu, Xiu-Feng Chen, and Li Ma, “Protective Effects of Bu-Shen-Huo-Xue Formula against 5/6 Nephrectomy-Induced Chronic Renal Failure in Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Chao Wu, Jiemei Jiang, Alex Boye, Yufeng Jiang, and Yan Yang, “Compound Astragalus and Salvia miltiorrhiza Extract Suppresses Rabbits' Hypertrophic Scar by Modulating the TGF-beta/Smad Signal,” Dermatology, vol. 229, no. 4, pp. 363–368, 2014. View at Publisher · View at Google Scholar
  • Qian Ji, Guo-Yin Zheng, Wei Xia, Jian-Yu Chen, Xiong-Yu Meng, Hong Zhang, Khalid Rahman, and Hai-Liang Xin, “Inhibition of invasion and metastasis of human liver cancer HCCLM3 cells by portulacerebroside A,” Pharmaceutical Biology, vol. 53, no. 5, pp. 773–780, 2015. View at Publisher · View at Google Scholar
  • Hai-Han Liao, Nan Zhang, Hong Feng, Ning Zhang, Zhen-Guo Ma, Zheng Yang, Yuan Yuan, Zhou-Yan Bian, and Qi-Zhu Tang, “Oleanolic acid alleviated pressure overload-induced cardiac remodeling,” Molecular And Cellular Biochemistry, vol. 409, no. 1-2, pp. 145–154, 2015. View at Publisher · View at Google Scholar
  • Qi Ye, Su-Juan Wang, Jian-Yu Chen, Khalid Rahman, Hai-Liang Xin, and Hong Zhang, “Medicinal Plants for the Treatment of Hypertrophic Scars,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–15, 2015. View at Publisher · View at Google Scholar