Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 843048, 6 pages
http://dx.doi.org/10.1155/2012/843048
Research Article
Metabolic Profiling Study of Yang Deficiency Syndrome in Hepatocellular Carcinoma by NMR and Pattern Recognition
1Department of TCM, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2Department of Oncology, Zhejiang Provincial Hospital of TCM, Zhejiang 310006, China
3School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Received 4 June 2012; Revised 16 August 2012; Accepted 27 August 2012
Academic Editor: Byeongsang Oh
Copyright © 2012 Xueqiang Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- M. B. Meng, Y. L. Cui, Y. S. Guan et al., “Traditional Chinese medicine plus transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma,” Journal of Alternative and Complementary Medicine, vol. 14, no. 8, pp. 1027–1042, 2008. View at Publisher · View at Google Scholar · View at Scopus
- Y. Yang, Q. Lang, Z. Chen et al., “The efficacy for unresectable hepatocellular carcinoma may be improved by transcatheter arterial chemoembolization in combination with a traditional Chinese herbal medicine formula: a retrospective study,” Cancer, vol. 115, no. 22, pp. 5132–5138, 2009. View at Publisher · View at Google Scholar · View at Scopus
- Y. J. Li, Z. Q. Fang, R. H. Di et al., “Statistical analysis of clinically reported syndromes differentiation of 2492 primary hepatocellular carcinoma cases,” Chinese Journal of Basic Medicine in Traditional Chinese Medicine, vol. 7, no. 6, pp. 69–71, 2001. View at Google Scholar
- J. K. Nicholson, J. C. Lindon, and E. Holmes, “‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data,” Xenobiotica, vol. 29, no. 11, pp. 1181–1189, 1999. View at Google Scholar · View at Scopus
- X. Wang, H. Sun, A. Zhang, W. Sun, P. Wang, and Z. Wang, “Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine,” Journal of Pharmaceutical and Biomedical Analysis, vol. 55, no. 5, pp. 859–868, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. Q. Ling, Q. Liu, D. T. Li et al., “Study of a qualitative diagnostic criterion for basic syndromes of traditional Chinese medicine in patients with primary liver cancer,” Journal of Chinese Integrative Medicine, vol. 3, no. 2, pp. 95–98, 2005. View at Google Scholar · View at Scopus
- D. T. Li, C. Q. Ling, and D. Z. Zhu, “Study on the quantitative evaluation on the degree of TCM basic syndromes often encountered in patients with primary liver cancer,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 27, no. 7, pp. 602–605, 2007. View at Google Scholar · View at Scopus
- O. Beckonert, H. C. Keun, T. M. Ebbels et al., “Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts,” Nature Protocols, vol. 2, no. 11, pp. 2692–2703, 2007. View at Publisher · View at Google Scholar · View at Scopus
- T. M. D. Ebbels and R. Cavill, “Bioinformatic methods in NMR-based metabolic profiling,” Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 55, no. 4, pp. 361–374, 2009. View at Publisher · View at Google Scholar · View at Scopus
- D. A. MacIntyre, B. Jiménez, E. J. Lewintre et al., “Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups,” Leukemia, vol. 24, no. 4, pp. 788–797, 2010. View at Publisher · View at Google Scholar · View at Scopus
- J. K. Nicholson, P. J. D. Foxall, M. Spraul, R. D. Farrant, and J. C. Lindon, “750 MHz and NMR spectroscopy of human blood plasma,” Analytical Chemistry, vol. 67, no. 5, pp. 793–811, 1995. View at Google Scholar · View at Scopus
- P. J. D. Foxall, M. Spraul, R. D. Farrant, L. C. Lindon, G. H. Neild, and J. K. Nicholson, “750 MHz 1H-NMR spectroscopy of human blood plasma,” Journal of Pharmaceutical and Biomedical Analysis, vol. 11, no. 4-5, pp. 267–276, 1993. View at Publisher · View at Google Scholar · View at Scopus
- Z. Y. Shen, J. H. Huang, and W. H. Chen, “Comparison of gene expression profiles between rats of Shen deficiency syndrome and Shen-yang deficiency syndrome differentiated according to therapeutic efficacy of drugs used,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 27, no. 2, pp. 135–137, 2007. View at Google Scholar · View at Scopus
- M. Chen, L. Zhao, and W. Jia, “Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model,” Journal of Proteome Research, vol. 4, no. 6, pp. 2391–2396, 2005. View at Publisher · View at Google Scholar · View at Scopus
- C. E. Sparks and J. D. Sparks, “Lipid metabolism: insights into the complexity of VLDL metabolic pathways,” Current Opinion in Lipidology, vol. 21, no. 3, pp. 280–281, 2010. View at Publisher · View at Google Scholar · View at Scopus
- V. Michel, R. K. Singh, and M. Bakovic, “The impact of choline availability on muscle lipid metabolism,” Food and Function, vol. 2, no. 1, pp. 53–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J. M. Wu, N. J. Skill, and M. A. Maluccio, “Evidence of aberrant lipid metabolism in hepatitis C and hepatocellular carcinoma,” HPB, vol. 12, no. 9, pp. 625–636, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. Watanabe, T. Higashi, T. Sakata, and H. Nagashima, “Serum amino acid levels in patients with hepatocellular carcinoma,” Cancer, vol. 54, no. 9, pp. 1875–1882, 1984. View at Google Scholar · View at Scopus
- A. V. Kurpad and M. Vaz, “Protein and amino acid requirements in the elderly,” European Journal of Clinical Nutrition, vol. 54, no. 3, pp. S131–S142, 2000. View at Google Scholar · View at Scopus
- P. M. Gullino, F. H. Grantham, and A. H. Courtney, “Glucose consumption by transplanted tumors in vivo,” Cancer Research, vol. 27, no. 6, pp. 1031–1040, 1967. View at Google Scholar · View at Scopus
- S. Passarella, L. de Bari, D. Valenti, R. Pizzuto, G. Paventi, and A. Atlante, “Mitochondria and l-lactate metabolism,” FEBS Letters, vol. 582, no. 25-26, pp. 3569–3576, 2008. View at Publisher · View at Google Scholar · View at Scopus
- L. A. Sauer and R. T. Dauchy, “Regulation of lactate production and utilization in rat tumors in vivo,” Journal of Biological Chemistry, vol. 260, no. 12, pp. 7496–7501, 1985. View at Google Scholar · View at Scopus