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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 845917, 12 pages
Review Article

Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress

1Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan
2Organization for Promotion of Regional Collaboration, University of Toyama, Toyama 930-8555, Japan

Received 24 February 2012; Accepted 17 April 2012

Academic Editor: William C. S. Cho

Copyright © 2012 Takako Yokozawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Green tea, prepared from the leaves of Camellia sinensis L., is a beverage that is popular worldwide. Polyphenols in green tea have been receiving much attention as potential compounds for the maintenance of human health due to their varied biological activity and low toxicity. In particular, the contribution of antioxidant activity to the prevention of diseases caused by oxidative stress has been focused upon. Therefore, in this study, we investigated the effects of (−)-epigallocatechin 3-O-gallate and (−)-epigallocatechin 3-O-gallate, which account for a large fraction of the components of green tea polyphenol, on oxidative stress-related renal disease. Our observations suggest that green tea polyphenols have a beneficial effect on pathological states related to oxidative stress of the kidney.