Alleviation of Morphine Withdrawal Signs but Not Tolerance by the
Essential Oil of Kelussia odoratissima Mozaff.
Figure 2
Effects of chronic administration of different doses of the essential oil of K. odoratissima on the number of (a) jumps and (b) stands. Morphine was given twice daily over a period of 5 days. The different doses of K. odoratissima, nifedipine, and vehicle were injected once a day during morphine injection at the morning for 4 days. The withdrawal signs was induced by naloxone (5 mg/kg) and recorded for 30 minutes. Naloxone was injected 2 hours after the final morphine injection. Results are the mean (±S.E.M.) from group of 6 mice. * for comparison with vehicle treated controls.
