Research Article

Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition

Figure 4

Nucleus damage in dentatin-treated prostate cancer cells. (a) Representative images of PC-3 and LNCaP cells treated with medium alone or with 15 μM dentatin, and stained with Hoechst 33342 for nucleus. Arrows showing condensed or fragmented nucleus. (b) Histogram showing fluorescence intensity of nucleus in PC-3 and LNCaP cells treated with various concentrations of dentatin or 10 μM paclitaxel, an anticancer drug. Data were shown as mean ± SD. .
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