Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Fig 1

Research Article

Aqueous Extract of Solanum nigrum Leaf Activates Autophagic Cell Death and Enhances Docetaxel-Induced Cytotoxicity in Human Endometrial Carcinoma Cells

Figure 1

Cytotoxicity of AE-SN in human endometrial cancer cells. (a–c) Results of MTT assay in HEC1A, HEC1B, and KLE cells. Cells were treated with 0, 0.05, 0.1, 0.2, 0.5, 1, 2 or 5 mg/mL AE-SN for 24, 48, or 72 hr. All three cell lines showed dose-dependent effects with AE-SN treatment at the three time points, as shown by one way ANOVA ( ). (d) Trypan blue exclusion test in HEC1A, HEC1B, and KLE cells. HEC1A and HEC1B cells were treated with 0, 0.1 or 0.5 mg/mL AE-SN, whereas KLE cells were treated with 0.5 and 2 mg/mL AE-SN for 48 hr. All three cell lines showed dose-dependent effects with AE-SN treatment, as shown by one-way ANOVA ( , 0.043, and 0.001 for HEC1A, HEC1B, and KLE cells, resp.). Experiments were done in triplicate, and all data are presented as .

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