Aqueous Extract of Solanum nigrum Leaf Activates Autophagic Cell Death and Enhances Docetaxel-Induced Cytotoxicity in Human Endometrial Carcinoma Cells

Table 1

Synergistic effect of AE-SN and docetaxel on human endometrial carcinoma cells HEC1A and HEC1B. By analyzing the cytotoxicity on AE-SN and docetaxel co-treated HEC1A and HEC1B cells, the combination index (CI) values were obtained. When the CI value is less than 1, the effect is considered synergistic.

Docetaxel (nM)	AE-SN (mg/mL)
	CI for HEC-1A		CI for HEC-1B
	0.2	0.5	0.2	0.5
0.001	16.7	55.36	33.08	162.49
0.01	35.25	42.36	15.78	162.49
0.1	10.41	42.37	15.8	4.99
0.5	3.43	24.73	1.72	4.99
1	0.67	1.08	0.43	0.19
5	0.08	0.08	0.06	0.11
10	0.06	0.01	0.01	0.03
50	0.11	0.02	0.02	0.01
100	0.19	0.07	0.04	0.02