Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8)

Table 2

Estimated 𝐾_𝑖 (μM) values for mOat1- and mOat3-mediated transport.

Compound	mOat1	mOat3	𝐾𝑖 ratio (mOat1/mOat3)
LSA	14.9±4.9	31.1±7.0	0.48
RMA	5.5±2.2	4.3±0.2	1.29
SAA	4.9±2.2	21.3±7.7	0.23

Values are reported as mean ± S.E.M. (𝑛=3). No significant differences between 𝐾_𝑖 values for mOat1 and mOat3 were detected (𝑃<0.05) as determined by Student’s unpaired 𝑡-test.