Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome

Table 2

NASH clinical research network scoring system.

	Item	Definition	Score/code
		Low-to-medium power evaluation of
		parenchymal involvement by steatosis
	Steatosis	<5%	0
		5–33%	1
		>33–66%	2
		>66%	3
NAS		Overall assessment of all inflammatory foci
		No foci	0
	Lobular inflammation	<2 foci per 200 × field	1
		2–4 foci per 200 × field	2
		>4 foci per 200 × field	3
		None	0
	Hepatocellular ballooning	Few balloon cells	1
		Many cells/prominent ballooning	2
			Full score: 8
		None	0
		Perisinusoidal or periportal	1
Fibrosis	Stage	Mild, zone 3, perisinusoidal	1A
		Moderate, zone 3, perisinusoidal	1B
		Portal/periportal	1C
		Perisinusoidal and portal/periportal	2
		Bridging fibrosis	3
		Cirrhosis	4